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GENE INFORMATION
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The gene information section lists the gene name (HUGO Gene Nomenclature Committee ( HGNC) name if available), any approved gene synonyms, Ensembl gene description, and the Entrez gene summary from the National Center for Biotechnology Information.
The chromosomal and cytoband location of the gene according to Ensembl is reported together with the Ensembl gene identifier and Ensembl database version. The Entrez gene identifier for the gene is also given. If any of the protein products of the gene is linked to a UniProt KB/SWISS-PROT entry, links to the UniProt and the neXtProt databases for these proteins are displayed.
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Gene name |
ATP5B (HGNC Symbol) |
Synonyms |
ATPSB |
Description |
ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide (HGNC Symbol) |
Entrez gene summary |
This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the beta subunit of the catalytic core. [provided by RefSeq, Jul 2008] |
Chromosome |
12 |
Cytoband |
q13.3 |
Chromosome location (bp) |
57031959 - 57039798 |
Protein evidence |
Evidence at protein level (all genes) |
Ensembl |
ENSG00000110955 (version 75.37) |
Entrez gene |
506 |
UniProt |
P06576 (UniProt - Evidence at protein level) |
neXtProt |
NX_P06576 |
Antibodypedia |
ATP5B antibodies |
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PROTEIN VIEW
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The protein view displays protein features. The tabs at the top of the protein view section can be used to switch between the different splice variants encoded by this gene. The mouse over function displays additional data for the features in the protein view.
At the top of the protein view, the maximum percent sequence identity of the protein to all other proteins from other human genes is shown, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50) ( read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0 and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green.
Common (purple) and unique (grey) regions between alternative processed transcripts from the same gene are also displayed ( read more), and at the bottom of the protein view is the protein scale.
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PROTEIN INFORMATION
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The protein information section displays the alternative protein-coding transcripts (splice variants) encoded by this gene, according to the Ensembl database.
The ENSP identifier links to the Ensembl website for that protein, and the ENST identifier links to the Ensembl website for that transcript. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes to which this protein has been assigned are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column.
The length of the protein (amino acid residues) (according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0 and Phobius and predicted transmembrane region(s) (according to MDM) are also reported.
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Splice variant |
Ensembl |
UniProt |
Protein class |
Gene ontology |
Length
(aa) |
Molecular mass
(kDa) |
Signal peptide
(predicted) |
Transmembrane regions
(predicted)
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| ATP5B-001 |
ENSP00000262030
ENST00000262030
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P06576
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P06576 [Direct mapping]ATP synthase subunit beta, mitochondrial Q0QEN7 [Target identity:84%; Query identity:100%]ATP synthase subunit beta
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Hydrolases
Enzymes
ENZYME proteins
Plasma proteins
Mitochondrial proteins
Cancer-related genes
Mutated cancer genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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529 |
56.6 |
No |
0 |
| ATP5B-002 |
ENSP00000450297
ENST00000552919
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F8VPV9
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F8VPV9 [Target identity:100%; Query identity:100%]ATP synthase subunit beta
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Cancer-related genes
Mutated cancer genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0015986 [ATP synthesis coupled proton transport] GO:0015991 [ATP hydrolysis coupled proton transport] GO:0015992 [proton transport] GO:0016820 [hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances] GO:0033178 [proton-transporting two-sector ATPase complex, catalytic domain] GO:0045261 [proton-transporting ATP synthase complex, catalytic core F(1)] GO:0046034 [ATP metabolic process] GO:0046933 [proton-transporting ATP synthase activity, rotational mechanism]
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518 |
55.3 |
No |
0 |
| ATP5B-003 |
ENSP00000446677
ENST00000551020
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F8W079
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F8W079 [Target identity:100%; Query identity:100%]ATP synthase subunit beta, mitochondrial
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Cancer-related genes
Mutated cancer genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding] GO:0005524 [ATP binding] GO:0015986 [ATP synthesis coupled proton transport] GO:0015991 [ATP hydrolysis coupled proton transport] GO:0015992 [proton transport] GO:0016820 [hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances] GO:0017111 [nucleoside-triphosphatase activity] GO:0033178 [proton-transporting two-sector ATPase complex, catalytic domain] GO:0046034 [ATP metabolic process] GO:0046933 [proton-transporting ATP synthase activity, rotational mechanism]
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284 |
30.2 |
No |
0 |
| ATP5B-004 |
ENSP00000446489
ENST00000552959
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SPOCTOPUS predicted membrane proteins
Cancer-related genes
Mutated cancer genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding] GO:0005524 [ATP binding] GO:0015986 [ATP synthesis coupled proton transport] GO:0015991 [ATP hydrolysis coupled proton transport] GO:0015992 [proton transport] GO:0016820 [hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances] GO:0017111 [nucleoside-triphosphatase activity] GO:0033178 [proton-transporting two-sector ATPase complex, catalytic domain] GO:0046034 [ATP metabolic process] GO:0046933 [proton-transporting ATP synthase activity, rotational mechanism]
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362 |
38.1 |
No |
0 |
| ATP5B-006 |
ENSP00000450233
ENST00000552104
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F8VQY0
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F8VQY0 [Target identity:100%; Query identity:100%]ATP synthase subunit beta, mitochondrial
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SPOCTOPUS predicted secreted proteins
Cancer-related genes
Mutated cancer genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005524 [ATP binding] GO:0015986 [ATP synthesis coupled proton transport] GO:0015991 [ATP hydrolysis coupled proton transport] GO:0015992 [proton transport] GO:0016820 [hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances] GO:0033178 [proton-transporting two-sector ATPase complex, catalytic domain] GO:0046034 [ATP metabolic process] GO:0046933 [proton-transporting ATP synthase activity, rotational mechanism]
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218 |
23.4 |
No |
0 |
| ATP5B-009 |
ENSP00000447571
ENST00000553007
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F8W0P7
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F8W0P7 [Target identity:100%; Query identity:100%]ATP synthase subunit beta, mitochondrial
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SPOCTOPUS predicted membrane proteins
Cancer-related genes
Mutated cancer genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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270 |
28.4 |
No |
0 |
| ATP5B-010 |
ENSP00000448428
ENST00000551570
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H0YI37
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H0YI37 [Target identity:100%; Query identity:100%]ATP synthase subunit beta, mitochondrial
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Cancer-related genes
Mutated cancer genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005524 [ATP binding] GO:0015986 [ATP synthesis coupled proton transport] GO:0046933 [proton-transporting ATP synthase activity, rotational mechanism]
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133 |
13.9 |
No |
0 |
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