TDP2

GENE INFORMATION

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Gene name

TDP2 (HGNC Symbol)

Synonyms

TTRAP

Description

Tyrosyl-DNA phosphodiesterase 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors. [provided by RefSeq, Jul 2008]

Chromosome

6

Cytoband

p22.3

Chromosome location (bp)

24650205 - 24667261

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000111802 (version 75.37)

Entrez gene

51567

UniProt

O95551 (UniProt - Evidence at protein level)

neXtProt

NX_O95551

Antibodypedia

TDP2 antibodies
 

PROTEIN VIEW

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TDP2-001
 
TDP2-002
 
TDP2-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TDP2-001 ENSP00000367440
ENST00000378198
O95551
Show all »
Show » Show » 362 40.9 No 0
TDP2-002 ENSP00000345345
ENST00000341060
Show » 304 34.5 Yes 0
TDP2-201 ENSP00000437637
ENST00000545995
O95551
Show all »
Show » Show » 392 44.3 No 0