FBXO5

GENE INFORMATION

? »

Gene name

FBXO5 (HGNC Symbol)

Synonyms

EMI1, FBX5, Fbxo31

Description

F-box protein 5 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is similar to xenopus early mitotic inhibitor-1 (Emi1), which is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Dec 2008]

Chromosome

6

Cytoband

q25.2

Chromosome location (bp)

153291664 - 153304714

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000112029 (version 75.37)

Entrez gene

26271

UniProt

Q9UKT4 (UniProt - Evidence at protein level)

neXtProt

NX_Q9UKT4

Antibodypedia

FBXO5 antibodies
 

PROTEIN VIEW

? »
 
 
 
FBXO5-001
 
FBXO5-002
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FBXO5-001 ENSP00000229758
ENST00000229758
Q9UKT4
Show all »
Show » Show » 447 50.1 No 0
FBXO5-002 ENSP00000356210
ENST00000367241
Q9UKT4
Show all »
Show » Show » 401 45.4 No 0