GMNN

GENE INFORMATION

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Gene name

GMNN (HGNC Symbol)

Synonyms

Gem

Description

Geminin, DNA replication inhibitor (HGNC Symbol)

Entrez gene summary

This gene encodes a protein that plays a critical role in cell cycle regulation. The encoded protein inhibits DNA replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance proteins into the pre-replication complex. The encoded protein is expressed during the S and G2 phases of the cell cycle and is degraded by the anaphase-promoting complex during the metaphase-anaphase transition. Increased expression of this gene may play a role in several malignancies including colon, rectal and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and two pseudogenes of this gene are located on the short arm of chromosome 16. [provided by RefSeq, Oct 2011]

Chromosome

6

Cytoband

p22.3

Chromosome location (bp)

24775159 - 24786327

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000112312 (version 75.37)

Entrez gene

51053

UniProt

O75496 (UniProt - Evidence at protein level)

neXtProt

NX_O75496

Antibodypedia

GMNN antibodies
 

PROTEIN VIEW

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GMNN-001
 
GMNN-002
 
GMNN-003
 
GMNN-004
 
GMNN-006
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GMNN-001 ENSP00000230056
ENST00000230056
O75496
Show all »
Show » Show » 209 23.6 No 0
GMNN-002 ENSP00000348902
ENST00000356509
O75496
Show all »
Show » Show » 209 23.6 No 0
GMNN-003 ENSP00000367293
ENST00000378054
E2QRF9
Show all »
Show » Show » 179 20.5 No 0
GMNN-004 ENSP00000419584
ENST00000476555
C9K0U5
Show all »
Show » Show » 66 7.3 No 0
GMNN-006 ENSP00000367298
ENST00000378059
H7C608
Show all »
Show » Show » 102 11.4 No 0