PACRG

GENE INFORMATION

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Gene name

PACRG (HGNC Symbol)

Synonyms

FLJ32724, Glup, HAK005771, PARK2CRG

Description

PARK2 co-regulated (HGNC Symbol)

Entrez gene summary

This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

6

Cytoband

q26

Chromosome location (bp)

163148164 - 163736524

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000112530 (version 75.37)

Entrez gene

135138

UniProt

Q96M98 (UniProt - Evidence at protein level)

neXtProt

NX_Q96M98

Antibodypedia

PACRG antibodies
 

PROTEIN VIEW

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PACRG-001
 
PACRG-002
 
PACRG-003
 
PACRG-004
 
PACRG-005
 
PACRG-007
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PACRG-001 ENSP00000355855
ENST00000366889
Q96M98
Show all »
Show » Show » 257 29.3 No 0
PACRG-002 ENSP00000355854
ENST00000366888
Q96M98
Show all »
Show » Show » 257 29.3 No 0
PACRG-003 ENSP00000337946
ENST00000337019
Q96M98
Show all »
Show » Show » 296 33.3 No 0
PACRG-004 ENSP00000440706
ENST00000541974
Show » 62 6.9 No 0
PACRG-005 ENSP00000442879
ENST00000534958
Show » Show » 125 14.3 No 0
PACRG-007 ENSP00000438242
ENST00000542936
Show » 127 14.3 No 1