SPARC - Gene info - The Human Protein Atlas

Gene name

SPARC (HGNC Symbol)

Synonyms

Description

Secreted protein, acidic, cysteine-rich (osteonectin) (HGNC Symbol)

Entrez gene summary

This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion. [provided by RefSeq, Dec 2011]

Chromosome

Cytoband

q33.1

Chromosome location (bp)

151040657 - 151066726

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000113140 (version 75.37)

Entrez gene

6678

UniProt

P09486 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SPARC-001

ENSP00000231061
ENST00000231061

P09486
Show all » « Hide

P09486 [Direct mapping]
SPARC
D3DQH8 [Target identity:100%; Query identity:96%]
Secreted protein, acidic, cysteine-rich (Osteonectin), isoform CRA_a
F5GY03 [Target identity:49%; Query identity:100%]
SPARC
E5RK62 [Target identity:37%; Query identity:100%]
SPARC
F5H4E2 [Target identity:36%; Query identity:100%]
SPARC
E5RJA5 [Target identity:17%; Query identity:100%]
SPARC

Show » « Hide

Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0001503 [ossification]
GO:0002576 [platelet degranulation]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005604 [basement membrane]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0007165 [signal transduction]
GO:0007507 [heart development]
GO:0007596 [blood coagulation]
GO:0009629 [response to gravity]
GO:0010288 [response to lead ion]
GO:0030168 [platelet activation]
GO:0030198 [extracellular matrix organization]
GO:0030324 [lung development]
GO:0031012 [extracellular matrix]
GO:0031093 [platelet alpha granule lumen]
GO:0031988 [membrane-bounded vesicle]
GO:0032496 [response to lipopolysaccharide]
GO:0033591 [response to L-ascorbic acid]
GO:0034097 [response to cytokine stimulus]
GO:0042060 [wound healing]
GO:0042127 [regulation of cell proliferation]
GO:0043434 [response to peptide hormone stimulus]
GO:0045471 [response to ethanol]
GO:0046686 [response to cadmium ion]
GO:0048839 [inner ear development]
GO:0050840 [extracellular matrix binding]
GO:0051384 [response to glucocorticoid stimulus]
GO:0051591 [response to cAMP]
GO:0051592 [response to calcium ion]
GO:0060348 [bone development]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071682 [endocytic vesicle lumen]

303

34.6

Yes

SPARC-004

ENSP00000429152
ENST00000522348

E5RJA5
Show all » « Hide

E5RJA5 [Target identity:100%; Query identity:100%]
SPARC

Show » « Hide

Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0001503 [ossification]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0007507 [heart development]
GO:0009629 [response to gravity]
GO:0010288 [response to lead ion]
GO:0030324 [lung development]
GO:0031012 [extracellular matrix]
GO:0031988 [membrane-bounded vesicle]
GO:0032496 [response to lipopolysaccharide]
GO:0033591 [response to L-ascorbic acid]
GO:0034097 [response to cytokine stimulus]
GO:0042060 [wound healing]
GO:0042127 [regulation of cell proliferation]
GO:0043434 [response to peptide hormone stimulus]
GO:0045471 [response to ethanol]
GO:0046686 [response to cadmium ion]
GO:0048839 [inner ear development]
GO:0050840 [extracellular matrix binding]
GO:0051384 [response to glucocorticoid stimulus]
GO:0051591 [response to cAMP]
GO:0051592 [response to calcium ion]
GO:0060348 [bone development]
GO:0071363 [cellular response to growth factor stimulus]

5.7

Yes

SPARC-005

ENSP00000428119
ENST00000521569

E5RK62
Show all » « Hide

E5RK62 [Target identity:100%; Query identity:100%]
SPARC

Show » « Hide

Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0001503 [ossification]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0007165 [signal transduction]
GO:0007507 [heart development]
GO:0009629 [response to gravity]
GO:0010288 [response to lead ion]
GO:0030324 [lung development]
GO:0031988 [membrane-bounded vesicle]
GO:0032496 [response to lipopolysaccharide]
GO:0033591 [response to L-ascorbic acid]
GO:0034097 [response to cytokine stimulus]
GO:0042060 [wound healing]
GO:0042127 [regulation of cell proliferation]
GO:0043434 [response to peptide hormone stimulus]
GO:0045471 [response to ethanol]
GO:0046686 [response to cadmium ion]
GO:0048839 [inner ear development]
GO:0050840 [extracellular matrix binding]
GO:0051384 [response to glucocorticoid stimulus]
GO:0051591 [response to cAMP]
GO:0051592 [response to calcium ion]
GO:0060348 [bone development]
GO:0071363 [cellular response to growth factor stimulus]

115

13.4

SPARC-007

ENSP00000444998
ENST00000539687

F5H4E2
Show all » « Hide

F5H4E2 [Target identity:100%; Query identity:100%]
SPARC
E5RJA5 [Target identity:47%; Query identity:100%]
SPARC

Show » « Hide

Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0001503 [ossification]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0007507 [heart development]
GO:0009629 [response to gravity]
GO:0010288 [response to lead ion]
GO:0030324 [lung development]
GO:0031012 [extracellular matrix]
GO:0031988 [membrane-bounded vesicle]
GO:0032496 [response to lipopolysaccharide]
GO:0033591 [response to L-ascorbic acid]
GO:0034097 [response to cytokine stimulus]
GO:0042060 [wound healing]
GO:0042127 [regulation of cell proliferation]
GO:0043434 [response to peptide hormone stimulus]
GO:0045471 [response to ethanol]
GO:0046686 [response to cadmium ion]
GO:0048839 [inner ear development]
GO:0050840 [extracellular matrix binding]
GO:0051384 [response to glucocorticoid stimulus]
GO:0051591 [response to cAMP]
GO:0051592 [response to calcium ion]
GO:0060348 [bone development]
GO:0071363 [cellular response to growth factor stimulus]

111

12.1

Yes

SPARC-008

ENSP00000440127
ENST00000538026

F5GY03
Show all » « Hide

F5GY03 [Target identity:100%; Query identity:100%]
SPARC
E5RK62 [Target identity:77%; Query identity:100%]
SPARC

Show » « Hide

Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

149

17.5

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.