PDE8B

GENE INFORMATION

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Gene name

PDE8B

Synonyms

Description

Phosphodiesterase 8B (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a cyclic nucleotide phosphodiesterase (PDE) that catalyzes the hydrolysis of the second messenger cAMP. The encoded protein, which does not hydrolyze cGMP, is resistant to several PDE inhibitors. Defects in this gene are a cause of autosomal dominant striatal degeneration (ADSD). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]

Chromosome

5

Cytoband

q13.3

Chromosome location (bp)

76506274 - 76725632

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000113231 (version 75.37)

Entrez gene

8622

UniProt

O95263 (UniProt - Evidence at protein level)

neXtProt

NX_O95263

Antibodypedia

PDE8B antibodies
 

PROTEIN VIEW

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PDE8B-001
 
PDE8B-002
 
PDE8B-003
 
PDE8B-004
 
PDE8B-005
 
PDE8B-006
 
PDE8B-007
 
PDE8B-008
 
PDE8B-009
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PDE8B-001 ENSP00000264917
ENST00000264917
O95263
Show all »
Show » Show » 885 99 No 0
PDE8B-002 ENSP00000345446
ENST00000340978
O95263
Show all »
Show » Show » 838 93.7 No 0
PDE8B-003 ENSP00000330428
ENST00000346042
O95263
Show all »
Show » Show » 788 88 No 0
PDE8B-004 ENSP00000345646
ENST00000342343
O95263
Show all »
Show » Show » 865 96.8 No 0
PDE8B-005 ENSP00000331336
ENST00000333194
O95263
Show all »
Show » Show » 830 93 No 0
PDE8B-006 ENSP00000423461
ENST00000505283
O95263
Show all »
Show » Show » 350 39.8 No 0
PDE8B-007 ENSP00000425720
ENST00000505926
D6RJD7
Show all »
Show » Show » 116 13.2 No 0
PDE8B-008 ENSP00000426200
ENST00000502945
D6RH10
Show all »
Show » Show » 112 12.7 No 0
PDE8B-009 ENSP00000422861
ENST00000503963
D6R9W0
Show all »
Show » Show » 119 13.6 No 0