LMNB1

GENE INFORMATION

? »

Gene name

LMNB1

Synonyms

Description

Lamin B1 (HGNC Symbol)

Entrez gene summary

The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1. Alternative splicing results in transcript variants and a duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). [provided by RefSeq, Oct 2010]

Chromosome

5

Cytoband

q23.2

Chromosome location (bp)

126112315 - 126172712

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000113368 (version 75.37)

Entrez gene

4001

UniProt

P20700 (UniProt - Evidence at protein level)

neXtProt

NX_P20700

Antibodypedia

LMNB1 antibodies
 

PROTEIN VIEW

? »
 
 
 
LMNB1-001
 
LMNB1-003
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

LMNB1-001 ENSP00000261366
ENST00000261366
P20700
Show all »
Show » Show » 586 66.4 No 0
LMNB1-003 ENSP00000378761
ENST00000395354
E9PBF6
Show all »
Show » Show » 387 44.6 No 0