ATP6V0E1

GENE INFORMATION

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Gene name

ATP6V0E1 (HGNC Symbol)

Synonyms

ATP6H, ATP6V0E, M9.2

Description

ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 (HGNC Symbol)

Entrez gene summary

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c"", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is possibly part of the V0 subunit. Since two nontranscribed pseudogenes have been found in dog, it is possible that the localization to chromosome 2 for this gene by radiation hybrid mapping is representing a pseudogene. Genomic mapping puts the chromosomal location on 5q35.3. [provided by RefSeq, Jul 2008]

Chromosome

5

Cytoband

q35.1

Chromosome location (bp)

172410760 - 172462448

Protein evidence

Evidence at transcript level (all genes)

Ensembl

ENSG00000113732 (version 75.37)

Entrez gene

8992

UniProt

O15342 (UniProt - Evidence at transcript level)

neXtProt

NX_O15342

Antibodypedia

ATP6V0E1 antibodies
 

PROTEIN VIEW

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ATP6V0E1-001
 
ATP6V0E1-002
 
ATP6V0E1-003
 
ATP6V0E1-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ATP6V0E1-001 ENSP00000429690
ENST00000519374
O15342
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Show » Show » 81 9.4 No 2
ATP6V0E1-002 ENSP00000430896
ENST00000519911
E5RHL5
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Show » Show » 58 6.5 No 2
ATP6V0E1-003 ENSP00000265093
ENST00000265093
J3KN48
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Show » Show » 65 7.6 No 1
ATP6V0E1-004 ENSP00000427941
ENST00000517669
O15342
Show all »
Show » Show » 81 9.4 No 2