HRG

GENE INFORMATION

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Gene name

HRG (HGNC Symbol)

Synonyms

HPRG, HRGP

Description

Histidine-rich glycoprotein (HGNC Symbol)

Entrez gene summary

This histidine-rich glycoprotein contains two cystatin-like domains and is located in plasma and platelets. The physiological function has not been determined but it is known that the protein binds heme, dyes and divalent metal ions. The encoded protein also has a peptide that displays antimicrobial activity against C. albicans, E. coli, S. aureus, P. aeruginosa, and E. faecalis. It can inhibit rosette formation and interacts with heparin, thrombospondin and plasminogen. Two of the protein's effects, the inhibition of fibrinolysis and the reduction of inhibition of coagulation, indicate a potential prothrombotic effect. Mutations in this gene lead to thrombophilia due to abnormal histidine-rich glycoprotein levels. [provided by RefSeq, Nov 2014]

Chromosome

3

Cytoband

q27.3

Chromosome location (bp)

186378005 - 186396029

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000113905 (version 75.37)

Entrez gene

3273

UniProt

P04196 (UniProt - Evidence at protein level)

neXtProt

NX_P04196

Antibodypedia

HRG antibodies
 

PROTEIN VIEW

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HRG-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HRG-001 ENSP00000232003
ENST00000232003
P04196
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