PRKAG3

GENE INFORMATION

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Gene name

PRKAG3

Synonyms

Description

Protein kinase, AMP-activated, gamma 3 non-catalytic subunit (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. It is dominantly expressed in skeletal muscle. Studies of the pig counterpart suggest that this subunit may play a key role in the regulation of energy metabolism in skeletal muscle. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

q35

Chromosome location (bp)

219687106 - 219696809

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000115592 (version 75.37)

Entrez gene

53632

UniProt

Q9UGI9 (UniProt - Evidence at protein level)

neXtProt

NX_Q9UGI9

Antibodypedia

PRKAG3 antibodies
 

PROTEIN VIEW

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PRKAG3-001
 
PRKAG3-003
 
PRKAG3-005
 
PRKAG3-006
 
PRKAG3-201
 
PRKAG3-202
 
PRKAG3-203
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PRKAG3-001 ENSP00000233944
ENST00000233944
Q9UGI9
Show all »
Show » Show » 489 54.3 No 0
PRKAG3-003 ENSP00000419272
ENST00000470307
B4DUK8
Show all »
Show » Show » 353 38.5 No 0
PRKAG3-005 ENSP00000416100
ENST00000430489
C9JIC7
Show all »
Show » 100 11 No 0
PRKAG3-006 ENSP00000436068
ENST00000529249
Q9UGI9
Show all »
Show » Show » 489 54.3 No 0
PRKAG3-201 ENSP00000375947
ENST00000392098
B4DUK8
Show all »
Show » Show » 353 38.5 No 0
PRKAG3-202 ENSP00000397133
ENST00000439262
Q9UGI9
Show all »
Show » Show » 464 51.5 No 0
PRKAG3-203 ENSP00000444536
ENST00000545803
B4DT70
Show all »
Show » Show » 305 34.4 No 0