IL18RAP

GENE INFORMATION

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Gene name

IL18RAP (HGNC Symbol)

Synonyms

AcPL, CD218b

Description

Interleukin 18 receptor accessory protein (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for interleukin 18 (IL18), a proinflammatory cytokine involved in inducing cell-mediated immunity. This protein enhances the IL18-binding activity of the IL18 receptor and plays a role in signaling by IL18. Mutations in this gene are associated with Crohn's disease and inflammatory bowel disease, and susceptibility to celiac disease and leprosy. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]

Chromosome

2

Cytoband

q12.1

Chromosome location (bp)

103035149 - 103069025

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000115607 (version 75.37)

Entrez gene

8807

UniProt

O95256 (UniProt - Evidence at protein level)

neXtProt

NX_O95256

Antibodypedia

IL18RAP antibodies
 

PROTEIN VIEW

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IL18RAP-001
 
IL18RAP-002
 
IL18RAP-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IL18RAP-001 ENSP00000264260
ENST00000264260
O95256
Show all »
Show » Show » 599 68.3 Yes 1
IL18RAP-002 ENSP00000387201
ENST00000409369
Q3KPE8
Show all »
Show » Show » 457 51.9 No 1
IL18RAP-003 ENSP00000389815
ENST00000450855
C9JLE2
Show all »
Show » 44 5.1 Yes 0