EPHA4 - Gene info - The Human Protein Atlas

Gene name

EPHA4 (HGNC Symbol)

Synonyms

Hek8, TYRO1

Description

EPH receptor A4 (HGNC Symbol)

Entrez gene summary

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. [provided by RefSeq, Jul 2008]

Chromosome

Cytoband

q36.1

Chromosome location (bp)

222282747 - 222438922

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000116106 (version 75.37)

Entrez gene

2043

UniProt

P54764 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

EPHA4-001

ENSP00000386829
ENST00000409938

P54764
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P54764 [Direct mapping]
Ephrin type-A receptor 4
E9PG71 [Target identity:96%; Query identity:100%]
Ephrin type-A receptor 4
Q53TA0 [Target identity:72%; Query identity:100%]
Putative uncharacterized protein EPHA4
Q584H6 [Target identity:27%; Query identity:100%]
Putative uncharacterized protein EPHA4
F5GZZ5 [Target identity:15%; Query identity:100%]
Ephrin type-A receptor 4
C9JEM6 [Target identity:12%; Query identity:100%]
Ephrin type-A receptor 4
C9JIX8 [Target identity:9%; Query identity:100%]
Ephrin type-A receptor 4

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   Transferases
   2TM proteins predicted by MDM
   Tyr protein kinases
   TMHMM predicted membrane proteins
   THUMBUP predicted membrane proteins
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Enzymes
   ENZYME proteins
   Kinases
Predicted membrane proteins
   Prediction method-based
   # TM segments-based
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005003 [ephrin receptor activity]
GO:0005004 [GPI-linked ephrin receptor activity]
GO:0005005 [transmembrane-ephrin receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005741 [mitochondrial outer membrane]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005887 [integral to plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007155 [cell adhesion]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007628 [adult walking behavior]
GO:0008045 [motor neuron axon guidance]
GO:0008347 [glial cell migration]
GO:0009986 [cell surface]
GO:0014069 [postsynaptic density]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0021957 [corticospinal tract morphogenesis]
GO:0030054 [cell junction]
GO:0030175 [filopodium]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0031594 [neuromuscular junction]
GO:0031901 [early endosome membrane]
GO:0032314 [regulation of Rac GTPase activity]
GO:0032317 [regulation of Rap GTPase activity]
GO:0042731 [PH domain binding]
GO:0043197 [dendritic spine]
GO:0043204 [perikaryon]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0043679 [axon terminus]
GO:0044295 [axonal growth cone]
GO:0045211 [postsynaptic membrane]
GO:0046777 [protein autophosphorylation]
GO:0046875 [ephrin receptor binding]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048681 [negative regulation of axon regeneration]
GO:0048710 [regulation of astrocyte differentiation]
GO:0050770 [regulation of axonogenesis]
GO:0050775 [positive regulation of dendrite morphogenesis]
GO:0061001 [regulation of dendritic spine morphogenesis]
GO:0097155 [fasciculation of sensory neuron axon]
GO:0097156 [fasciculation of motor neuron axon]
GO:0097161 [DH domain binding]
GO:2001108 [positive regulation of Rho guanyl-nucleotide exchange factor activity]

986

109.9

Yes

EPHA4-002

ENSP00000444085
ENST00000541600

F5GZZ5
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F5GZZ5 [Target identity:100%; Query identity:100%]
Ephrin type-A receptor 4
C9JIX8 [Target identity:61%; Query identity:100%]
Ephrin type-A receptor 4

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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0005004 [GPI-linked ephrin receptor activity]
GO:0005005 [transmembrane-ephrin receptor activity]
GO:0005741 [mitochondrial outer membrane]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005887 [integral to plasma membrane]
GO:0007628 [adult walking behavior]
GO:0008045 [motor neuron axon guidance]
GO:0008347 [glial cell migration]
GO:0009986 [cell surface]
GO:0014069 [postsynaptic density]
GO:0021957 [corticospinal tract morphogenesis]
GO:0030175 [filopodium]
GO:0031594 [neuromuscular junction]
GO:0031901 [early endosome membrane]
GO:0032314 [regulation of Rac GTPase activity]
GO:0032317 [regulation of Rap GTPase activity]
GO:0043197 [dendritic spine]
GO:0043204 [perikaryon]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0043679 [axon terminus]
GO:0044295 [axonal growth cone]
GO:0046875 [ephrin receptor binding]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048681 [negative regulation of axon regeneration]
GO:0048710 [regulation of astrocyte differentiation]
GO:0050770 [regulation of axonogenesis]
GO:0050775 [positive regulation of dendrite morphogenesis]
GO:0061001 [regulation of dendritic spine morphogenesis]
GO:0097155 [fasciculation of sensory neuron axon]
GO:0097156 [fasciculation of motor neuron axon]

149

17.2

Yes

EPHA4-003

ENSP00000386276
ENST00000409854

E9PG71
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E9PG71 [Target identity:100%; Query identity:100%]
Ephrin type-A receptor 4
Q584H6 [Target identity:28%; Query identity:100%]
Putative uncharacterized protein EPHA4
F5GZZ5 [Target identity:15%; Query identity:100%]
Ephrin type-A receptor 4
C9JEM6 [Target identity:13%; Query identity:100%]
Ephrin type-A receptor 4
C9JIX8 [Target identity:9%; Query identity:100%]
Ephrin type-A receptor 4

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   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   2TM proteins predicted by MDM
Predicted membrane proteins
   Prediction method-based
   # TM segments-based
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005003 [ephrin receptor activity]
GO:0005004 [GPI-linked ephrin receptor activity]
GO:0005005 [transmembrane-ephrin receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005741 [mitochondrial outer membrane]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005887 [integral to plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007628 [adult walking behavior]
GO:0008045 [motor neuron axon guidance]
GO:0008347 [glial cell migration]
GO:0009986 [cell surface]
GO:0014069 [postsynaptic density]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]
GO:0021957 [corticospinal tract morphogenesis]
GO:0030175 [filopodium]
GO:0031594 [neuromuscular junction]
GO:0031901 [early endosome membrane]
GO:0032314 [regulation of Rac GTPase activity]
GO:0032317 [regulation of Rap GTPase activity]
GO:0043197 [dendritic spine]
GO:0043204 [perikaryon]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0043679 [axon terminus]
GO:0044295 [axonal growth cone]
GO:0046875 [ephrin receptor binding]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048681 [negative regulation of axon regeneration]
GO:0048710 [regulation of astrocyte differentiation]
GO:0050770 [regulation of axonogenesis]
GO:0050775 [positive regulation of dendrite morphogenesis]
GO:0061001 [regulation of dendritic spine morphogenesis]
GO:0097155 [fasciculation of sensory neuron axon]
GO:0097156 [fasciculation of motor neuron axon]

949

105.7

Yes

EPHA4-004

ENSP00000404089
ENST00000434266

C9JIX8
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C9JIX8 [Target identity:100%; Query identity:100%]
Ephrin type-A receptor 4

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10.3

Yes

EPHA4-005

ENSP00000410158
ENST00000419964

C9JEM6
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C9JEM6 [Target identity:100%; Query identity:100%]
Ephrin type-A receptor 4

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Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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126

14.9

EPHA4-006

ENSP00000401405
ENST00000441679

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Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0005515 [protein binding]

189

20.1

EPHA4-009

ENSP00000408145
ENST00000424339

H7C2W7
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H7C2W7 [Target identity:100%; Query identity:100%]
Ephrin type-A receptor 4

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Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]

4.5

EPHA4-012

ENSP00000395917
ENST00000443796

C9JFX5
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C9JFX5 [Target identity:100%; Query identity:100%]
Ephrin type-A receptor 4

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   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0005515 [protein binding]

177

Yes

EPHA4-013

ENSP00000391517
ENST00000415749

F8WBU0
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F8WBU0 [Target identity:100%; Query identity:100%]
Ephrin type-A receptor 4

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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

4.1

Yes

EPHA4-201

ENSP00000281821
ENST00000281821

P54764
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Show » « Hide

GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005003 [ephrin receptor activity]
GO:0005004 [GPI-linked ephrin receptor activity]
GO:0005005 [transmembrane-ephrin receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005741 [mitochondrial outer membrane]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral to plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007155 [cell adhesion]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007411 [axon guidance]
GO:0007628 [adult walking behavior]
GO:0008045 [motor neuron axon guidance]
GO:0008347 [glial cell migration]
GO:0009986 [cell surface]
GO:0014069 [postsynaptic density]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0021957 [corticospinal tract morphogenesis]
GO:0030054 [cell junction]
GO:0030175 [filopodium]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0031594 [neuromuscular junction]
GO:0031901 [early endosome membrane]
GO:0032314 [regulation of Rac GTPase activity]
GO:0032317 [regulation of Rap GTPase activity]
GO:0032319 [regulation of Rho GTPase activity]
GO:0042731 [PH domain binding]
GO:0042802 [identical protein binding]
GO:0042995 [cell projection]
GO:0043197 [dendritic spine]
GO:0043204 [perikaryon]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0043679 [axon terminus]
GO:0044295 [axonal growth cone]
GO:0044297 [cell body]
GO:0045211 [postsynaptic membrane]
GO:0046777 [protein autophosphorylation]
GO:0046875 [ephrin receptor binding]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048681 [negative regulation of axon regeneration]
GO:0048710 [regulation of astrocyte differentiation]
GO:0050770 [regulation of axonogenesis]
GO:0050775 [positive regulation of dendrite morphogenesis]
GO:0061001 [regulation of dendritic spine morphogenesis]
GO:0097155 [fasciculation of sensory neuron axon]
GO:0097156 [fasciculation of motor neuron axon]
GO:0097161 [DH domain binding]
GO:2001108 [positive regulation of Rho guanyl-nucleotide exchange factor activity]

986

109.9

Yes

EPHA4-202

ENSP00000375923
ENST00000392071

B7Z6Q8
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B7Z6Q8 [Target identity:100%; Query identity:100%]
Ephrin type-A receptor 4; cDNA FLJ53205, highly similar to Ephrin type-A receptor 4
Q53TA0 [Target identity:76%; Query identity:100%]
Putative uncharacterized protein EPHA4
C9JEM6 [Target identity:13%; Query identity:100%]
Ephrin type-A receptor 4

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GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005003 [ephrin receptor activity]
GO:0005004 [GPI-linked ephrin receptor activity]
GO:0005005 [transmembrane-ephrin receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005741 [mitochondrial outer membrane]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005887 [integral to plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007628 [adult walking behavior]
GO:0008045 [motor neuron axon guidance]
GO:0008347 [glial cell migration]
GO:0009986 [cell surface]
GO:0014069 [postsynaptic density]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]
GO:0021957 [corticospinal tract morphogenesis]
GO:0030175 [filopodium]
GO:0031594 [neuromuscular junction]
GO:0031901 [early endosome membrane]
GO:0032314 [regulation of Rac GTPase activity]
GO:0032317 [regulation of Rap GTPase activity]
GO:0043197 [dendritic spine]
GO:0043204 [perikaryon]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0043679 [axon terminus]
GO:0044295 [axonal growth cone]
GO:0046875 [ephrin receptor binding]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048681 [negative regulation of axon regeneration]
GO:0048710 [regulation of astrocyte differentiation]
GO:0050770 [regulation of axonogenesis]
GO:0050775 [positive regulation of dendrite morphogenesis]
GO:0061001 [regulation of dendritic spine morphogenesis]
GO:0097155 [fasciculation of sensory neuron axon]
GO:0097156 [fasciculation of motor neuron axon]

935

104.5

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.