TPSG1

GENE INFORMATION

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Gene name

TPSG1 (HGNC Symbol)

Synonyms

PRSS31, TMT

Description

Tryptase gamma 1 (HGNC Symbol)

Entrez gene summary

Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. There is uncertainty regarding the number of genes in this cluster. Currently four functional genes - alpha I, beta I, beta II and gamma I - have been identified. And beta I has an allelic variant named alpha II, beta II has an allelic variant beta III, also gamma I has an allelic variant gamma II. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha-tryptases predominant. This gene differs from other members of the tryptase gene family in that it has C-terminal hydrophobic domain, which may serve as a membrane anchor. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. [provided by RefSeq, Jul 2008]

Chromosome

16

Cytoband

p13.3

Chromosome location (bp)

1271651 - 1275257

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000116176 (version 75.37)

Entrez gene

25823

UniProt

Q9NRR2 (UniProt - Evidence at transcript level)

neXtProt

NX_Q9NRR2

Antibodypedia

TPSG1 antibodies
 

PROTEIN VIEW

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TPSG1-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TPSG1-001 ENSP00000234798
ENST00000234798
Q9NRR2
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