MTR

GENE INFORMATION

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Gene name

MTR (HGNC Symbol)

Synonyms

cblG

Description

5-methyltetrahydrofolate-homocysteine methyltransferase (HGNC Symbol)

Entrez gene summary

This gene encodes the 5-methyltetrahydrofolate-homocysteine methyltransferase. This enzyme, also known as cobalamin-dependent methionine synthase, catalyzes the final step in methionine biosynthesis. Mutations in MTR have been identified as the underlying cause of methylcobalamin deficiency complementation group G. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]

Chromosome

1

Cytoband

q43

Chromosome location (bp)

236958610 - 237067281

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000116984 (version 75.37)

Entrez gene

4548

UniProt

Q99707 (UniProt - Evidence at protein level)

neXtProt

NX_Q99707

Antibodypedia

MTR antibodies
 

PROTEIN VIEW

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MTR-001
 
MTR-002
 
MTR-201
 
MTR-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MTR-001 ENSP00000355536
ENST00000366577
Q99707
Show all »
Show » Show » 1265 140.5 No 0
MTR-002 ENSP00000355535
ENST00000366576
B1ANE3
Show all »
Show » Show » 819 91.8 No 0
MTR-201 ENSP00000402255
ENST00000418145
B4DFV0
Show all »
Show » Show » 229 24.3 Yes 0
MTR-202 ENSP00000441845
ENST00000535889
B7ZLW7
Show all »
Show » Show » 1214 134.8 No 0