CENPF

GENE INFORMATION

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Gene name

CENPF (HGNC Symbol)

Synonyms

hcp-1

Description

Centromere protein F, 350/400kDa (HGNC Symbol)

Entrez gene summary

This gene encodes a protein that associates with the centromere-kinetochore complex. The protein is a component of the nuclear matrix during the G2 phase of interphase. In late G2 the protein associates with the kinetochore and maintains this association through early anaphase. It localizes to the spindle midzone and the intracellular bridge in late anaphase and telophase, respectively, and is thought to be subsequently degraded. The localization of this protein suggests that it may play a role in chromosome segregation during mitotis. It is thought to form either a homodimer or heterodimer. Autoantibodies against this protein have been found in patients with cancer or graft versus host disease. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

q41

Chromosome location (bp)

214776538 - 214837931

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000117724 (version 75.37)

Entrez gene

1063

UniProt

P49454 (UniProt - Evidence at protein level)

neXtProt

NX_P49454

Antibodypedia

CENPF antibodies
 

PROTEIN VIEW

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CENPF-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CENPF-001 ENSP00000355922
ENST00000366955
P49454
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