MMP8

GENE INFORMATION

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Gene name

MMP8 (HGNC Symbol)

Synonyms

CLG1

Description

Matrix metallopeptidase 8 (neutrophil collagenase) (HGNC Symbol)

Entrez gene summary

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is stored in secondary granules within neutrophils and is activated by autolytic cleavage. Its function is degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]

Chromosome

11

Cytoband

q22.2

Chromosome location (bp)

102582526 - 102597781

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000118113 (version 75.37)

Entrez gene

4317

UniProt

P22894 (UniProt - Evidence at protein level)

neXtProt

NX_P22894

Antibodypedia

MMP8 antibodies
 

PROTEIN VIEW

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MMP8-001
 
MMP8-002
 
MMP8-004
 
MMP8-005
 
MMP8-006
 
MMP8-007
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MMP8-001 ENSP00000236826
ENST00000236826
P22894
Show all »
Show » Show » 467 53.4 Yes 0
MMP8-002 ENSP00000431431
ENST00000528662
E9PL87
Show all »
Show » 36 4.1 Yes 0
MMP8-004 ENSP00000401004
ENST00000438475
Show » Show » 344 39.1 No 0
MMP8-005 ENSP00000431938
ENST00000532799
E9PIY7
Show all »
Show » 43 5 Yes 0
MMP8-006 ENSP00000433812
ENST00000531168
E9PJB3
Show all »
Show » 56 6.2 Yes 0
MMP8-007 ENSP00000437173
ENST00000533258
E9PJB3
Show all »
Show » 56 6.2 Yes 0