CRYGD

GENE INFORMATION

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Gene name

CRYGD (HGNC Symbol)

Synonyms

CRYG4

Description

Crystallin, gamma D (HGNC Symbol)

Entrez gene summary

Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. They are differentially regulated after early development. Four gamma-crystallin genes (gamma-A through gamma-D) and three pseudogenes (gamma-E, gamma-F, gamma-G) are tandemly organized in a genomic segment as a gene cluster. Whether due to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

q33.3

Chromosome location (bp)

208986331 - 208989225

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000118231 (version 75.37)

Entrez gene

1421

UniProt

P07320 (UniProt - Evidence at protein level)

neXtProt

NX_P07320

Antibodypedia

CRYGD antibodies
 

PROTEIN VIEW

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CRYGD-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CRYGD-001 ENSP00000264376
ENST00000264376
P07320
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