TNFAIP3

GENE INFORMATION

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Gene name

TNFAIP3 (HGNC Symbol)

Synonyms

A20, OTUD7C

Description

Tumor necrosis factor, alpha-induced protein 3 (HGNC Symbol)

Entrez gene summary

This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2012]

Chromosome

6

Cytoband

q23.3

Chromosome location (bp)

138188351 - 138204449

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000118503 (version 75.37)

Entrez gene

7128

UniProt

P21580 (UniProt - Evidence at protein level)

neXtProt

NX_P21580

Antibodypedia

TNFAIP3 antibodies
 

PROTEIN VIEW

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TNFAIP3-001
 
TNFAIP3-002
 
TNFAIP3-003
 
TNFAIP3-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TNFAIP3-001 ENSP00000237289
ENST00000237289
P21580
Show all »
Show » Show » 790 89.6 No 0
TNFAIP3-002 ENSP00000393577
ENST00000421450
Q5VXR0
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Show » Show » 26 3 No 0
TNFAIP3-003 ENSP00000401562
ENST00000420009
Q5VXQ8
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Show » Show » 162 19.2 No 0
TNFAIP3-004 ENSP00000409845
ENST00000433680
Q5VXQ9
Show all »
Show » Show » 98 11.8 No 0