SPP1

GENE INFORMATION

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Gene name

SPP1 (HGNC Symbol)

Synonyms

BNSP, BSPI, ETA-1, OPN

Description

Secreted phosphoprotein 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Chromosome

4

Cytoband

q22.1

Chromosome location (bp)

88896819 - 88904562

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000118785 (version 75.37)

Entrez gene

6696

UniProt

P10451 (UniProt - Evidence at protein level)

neXtProt

NX_P10451

Antibodypedia

SPP1 antibodies
 

PROTEIN VIEW

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SPP1-001
 
SPP1-002
 
SPP1-003
 
SPP1-010
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SPP1-001 ENSP00000378517
ENST00000395080
P10451
Show all »
Show » Show » 314 35.4 Yes 0
SPP1-002 ENSP00000237623
ENST00000237623
P10451
Show all »
Show » Show » 300 33.8 Yes 0
SPP1-003 ENSP00000354042
ENST00000360804
P10451
Show all »
Show » Show » 287 32.4 Yes 0
SPP1-010 ENSP00000422973
ENST00000508233
D6R9C5
Show all »
Show » Show » 241 27.1 Yes 0