PPL

GENE INFORMATION

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Gene name

PPL

Synonyms

Description

Periplakin (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling. [provided by RefSeq, Jul 2008]

Chromosome

16

Cytoband

p13.3

Chromosome location (bp)

4932508 - 5010742

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000118898 (version 75.37)

Entrez gene

5493

UniProt

O60437 (UniProt - Evidence at protein level)

neXtProt

NX_O60437

Antibodypedia

PPL antibodies
 

PROTEIN VIEW

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PPL-001
 
PPL-002
 
PPL-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PPL-001 ENSP00000340510
ENST00000345988
O60437
Show all »
Show » Show » 1756 204.7 No 0
PPL-002 ENSP00000467699
ENST00000592772
K7EQ71
Show all »
Show » Show » 1115 131.4 No 0
PPL-003 ENSP00000465640
ENST00000590782
K7EKI8
Show all »
Show » Show » 1754 204.5 No 0