LRAT

GENE INFORMATION

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Gene name

LRAT

Synonyms

Description

Lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene localizes to the endoplasmic reticulum, where it catalyzes the esterification of all-trans-retinol into all-trans-retinyl ester. This reaction is an important step in vitamin A metabolism in the visual system. Mutations in this gene have been associated with early-onset severe retinal dystrophy and Leber congenital amaurosis 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]

Chromosome

4

Cytoband

q31.3

Chromosome location (bp)

155548097 - 155674270

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000121207 (version 75.37)

Entrez gene

9227

UniProt

O95237 (UniProt - Evidence at protein level)

neXtProt

NX_O95237

Antibodypedia

LRAT antibodies
 

PROTEIN VIEW

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LRAT-002
 
LRAT-004
 
LRAT-005
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

LRAT-002 ENSP00000422324
ENST00000502525
D6RC94
Show all »
Show » Show » 69 7.8 Yes 0
LRAT-004 ENSP00000426761
ENST00000507827
O95237
Show all »
Show » Show » 230 25.7 Yes 1
LRAT-005 ENSP00000337224
ENST00000336356
O95237
Show all »
Show » Show » 230 25.7 Yes 1