LDB3

GENE INFORMATION

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Gene name

LDB3 (HGNC Symbol)

Synonyms

KIAA0613, PDLIM6, ZASP

Description

LIM domain binding 3 (HGNC Symbol)

Entrez gene summary

This gene encodes a PDZ domain-containing protein. PDZ motifs are modular protein-protein interaction domains consisting of 80-120 amino acid residues. PDZ domain-containing proteins interact with each other in cytoskeletal assembly or with other proteins involved in targeting and clustering of membrane proteins. The protein encoded by this gene interacts with alpha-actinin-2 through its N-terminal PDZ domain and with protein kinase C via its C-terminal LIM domains. The LIM domain is a cysteine-rich motif defined by 50-60 amino acids containing two zinc-binding modules. This protein also interacts with all three members of the myozenin family. Mutations in this gene have been associated with myofibrillar myopathy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been identified; all isoforms have N-terminal PDZ domains while only longer isoforms (1, 2 and 5) have C-terminal LIM domains. [provided by RefSeq, Jan 2010]

Chromosome

10

Cytoband

q23.2

Chromosome location (bp)

88428206 - 88495825

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000122367 (version 75.37)

Entrez gene

11155

UniProt

O75112 (UniProt - Evidence at protein level)

neXtProt

NX_O75112

Antibodypedia

LDB3 antibodies
 

PROTEIN VIEW

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LDB3-001
 
LDB3-002
 
LDB3-201
 
LDB3-202
 
LDB3-203
 
LDB3-204
 
LDB3-205
 
LDB3-206
 
LDB3-207
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

LDB3-001 ENSP00000355296
ENST00000361373
O75112
Show all »
Show » Show » 727 77.1 No 0
LDB3-002 ENSP00000361136
ENST00000372066
O75112
Show all »
Show » Show » 283 31 No 0
LDB3-201 ENSP00000263066
ENST00000263066
O75112
Show all »
Show » Show » 617 66.7 No 0
LDB3-202 ENSP00000311913
ENST00000310944
O75112
Show all »
Show » Show » 330 35.6 No 0
LDB3-203 ENSP00000263067
ENST00000352360
O75112
Show all »
Show » Show » 470 50.6 No 0
LDB3-204 ENSP00000361126
ENST00000372056
O75112
Show all »
Show » Show » 398 42.8 No 0
LDB3-205 ENSP00000401437
ENST00000429277
O75112
Show all »
Show » Show » 732 78.5 No 0
LDB3-206 ENSP00000409148
ENST00000458213
O75112
Show all »
Show » Show » 617 66.7 No 0
LDB3-207 ENSP00000438866
ENST00000542786
O75112
Show all »
Show » Show » 231 24.3 No 0