C4BPB

GENE INFORMATION

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Gene name

C4BPB (HGNC Symbol)

Synonyms

C4BP

Description

Complement component 4 binding protein, beta (HGNC Symbol)

Entrez gene summary

This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Alternative splicing gives rise to multiple transcript variants. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

q32.2

Chromosome location (bp)

207262187 - 207273338

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000123843 (version 75.37)

Entrez gene

725

UniProt

P20851 (UniProt - Evidence at protein level)

neXtProt

NX_P20851

Antibodypedia

C4BPB antibodies
 

PROTEIN VIEW

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C4BPB-001
 
C4BPB-002
 
C4BPB-003
 
C4BPB-004
 
C4BPB-201
 
C4BPB-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

C4BPB-001 ENSP00000243611
ENST00000243611
P20851
Show all »
Show » Show » 252 28.4 Yes 0
C4BPB-002 ENSP00000356043
ENST00000367076
P20851
Show all »
Show » Show » 251 28.3 Yes 0
C4BPB-003 ENSP00000356045
ENST00000367078
P20851
Show all »
Show » Show » 252 28.4 Yes 0
C4BPB-004 ENSP00000392237
ENST00000452902
Q5VVQ7
Show all »
Show » 181 20.3 Yes 0
C4BPB-201 ENSP00000375790
ENST00000391923
P20851
Show all »
Show » Show » 252 28.4 Yes 0
C4BPB-202 ENSP00000405649
ENST00000451804
E7EQT9
Show all »
Show » 218 24.2 No 0