PTGIS

GENE INFORMATION

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Gene name

PTGIS (HGNC Symbol)

Synonyms

CYP8A1, PGIS

Description

Prostaglandin I2 (prostacyclin) synthase (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis. [provided by RefSeq, Jul 2008]

Chromosome

20

Cytoband

q13.13

Chromosome location (bp)

48120411 - 48184683

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000124212 (version 75.37)

Entrez gene

5740

UniProt

Q16647 (UniProt - Evidence at protein level)

neXtProt

NX_Q16647

Antibodypedia

PTGIS antibodies
 

PROTEIN VIEW

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PTGIS-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PTGIS-001 ENSP00000244043
ENST00000244043
Q16647
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