SSX1

GENE INFORMATION

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Gene name

SSX1 (HGNC Symbol)

Synonyms

CT5.1

Description

Synovial sarcoma, X breakpoint 1 (HGNC Symbol)

Entrez gene summary

The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. This gene, and also the SSX2 and SSX4 family members, have been involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are likely responsible for transforming activity. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome X. [provided by RefSeq, Jul 2013]

Chromosome

X

Cytoband

p11.23

Chromosome location (bp)

48114752 - 48126879

Protein evidence

Evidence at transcript level (all genes)

Ensembl

ENSG00000126752 (version 75.37)

Entrez gene

6756

UniProt

Q16384 (UniProt - Evidence at transcript level)

neXtProt

NX_Q16384

Antibodypedia

SSX1 antibodies
 

PROTEIN VIEW

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SSX1-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SSX1-001 ENSP00000366118
ENST00000376919
Q16384
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