APOBEC3A

GENE INFORMATION

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Gene name

APOBEC3A (HGNC Symbol)

Synonyms

ARP3, PHRBN

Description

Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A (HGNC Symbol)

Entrez gene summary

This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene lacks the zinc binding activity of other family members. The protein plays a role in immunity, by restricting transmission of foreign DNA such as viruses. One mechanism of foreign DNA restriction is deamination of foreign double-stranded DNA cytidines to uridines, which leads to DNA degradation. However, other mechanisms are also thought to be involved, as anti-viral effect is not dependent on deaminase activity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]

Chromosome

22

Cytoband

q13.1

Chromosome location (bp)

39348746 - 39359188

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000128383 (version 75.37)

Entrez gene

200315

UniProt

P31941 (UniProt - Evidence at protein level)

neXtProt

NX_P31941

Antibodypedia

APOBEC3A antibodies
 

PROTEIN VIEW

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APOBEC3A-001
 
APOBEC3A-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

APOBEC3A-001 ENSP00000384359
ENST00000402255
P31941
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APOBEC3A-201 ENSP00000249116
ENST00000249116
P31941
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