HOXD10

GENE INFORMATION

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Gene name

HOXD10 (HGNC Symbol)

Synonyms

HOX4, HOX4D

Description

Homeobox D10 (HGNC Symbol)

Entrez gene summary

This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox D genes located on chromosome 2. The encoded nuclear protein functions as a sequence-specific transcription factor that is expressed in the developing limb buds and is involved in differentiation and limb development. Mutations in this gene have been associated with Wilm's tumor and congenital vertical talus (also known as ""rocker-bottom foot"" deformity or congenital convex pes valgus) and/or a foot deformity resembling that seen in Charcot-Marie-Tooth disease. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

q31.1

Chromosome location (bp)

176973518 - 176984670

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000128710 (version 75.37)

Entrez gene

3236

UniProt

P28358 (UniProt - Evidence at protein level)

neXtProt

NX_P28358

Antibodypedia

HOXD10 antibodies
 

PROTEIN VIEW

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HOXD10-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HOXD10-001 ENSP00000249501
ENST00000249501
P28358
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