TPH1

GENE INFORMATION

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Gene name

TPH1 (HGNC Symbol)

Synonyms

TPH, TPRH

Description

Tryptophan hydroxylase 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others.[provided by RefSeq, Apr 2009]

Chromosome

11

Cytoband

p15.1

Chromosome location (bp)

18039111 - 18063973

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000129167 (version 75.37)

Entrez gene

7166

UniProt

P17752 (UniProt - Evidence at protein level)

neXtProt

NX_P17752

Antibodypedia

TPH1 antibodies
 

PROTEIN VIEW

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TPH1-001
 
TPH1-002
 
TPH1-004
 
TPH1-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TPH1-001 ENSP00000250018
ENST00000250018
P17752
Show all »
Show » Show » 444 51 No 0
TPH1-002 ENSP00000403831
ENST00000417164
E7EMX4
Show all »
Show » 206 24.4 No 0
TPH1-004 ENSP00000436081
ENST00000528338
E9PR49
Show all »
Show » 165 19.4 No 0
TPH1-201 ENSP00000343550
ENST00000341556
P17752
Show all »
Show » Show » 466 53.4 No 0