TNNI2

GENE INFORMATION

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Gene name

TNNI2 (HGNC Symbol)

Synonyms

AMCD2B, DA2B, FSSV

Description

Troponin I type 2 (skeletal, fast) (HGNC Symbol)

Entrez gene summary

This gene encodes a fast-twitch skeletal muscle protein, a member of the troponin I gene family, and a component of the troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, along with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. Mouse studies show that this component is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function. In addition to muscle tissues, this protein is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a co-activator of estrogen receptor-related receptor alpha. This protein also suppresses tumor growth in human ovarian carcinoma. Mutations in this gene cause myopathy and distal arthrogryposis type 2B. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]

Chromosome

11

Cytoband

p15.5

Chromosome location (bp)

1860219 - 1862910

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000130598 (version 75.37)

Entrez gene

7136

UniProt

P48788 (UniProt - Evidence at protein level)

neXtProt

NX_P48788

Antibodypedia

TNNI2 antibodies
 

PROTEIN VIEW

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TNNI2-001
 
TNNI2-002
 
TNNI2-003
 
TNNI2-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TNNI2-001 ENSP00000371331
ENST00000381906
P48788
Show all »
Show » Show » 182 21.3 No 0
TNNI2-002 ENSP00000371336
ENST00000381911
P48788
Show all »
Show » Show » 182 21.3 No 0
TNNI2-003 ENSP00000371330
ENST00000381905
P48788
Show all »
Show » Show » 182 21.4 No 0
TNNI2-201 ENSP00000252898
ENST00000252898
P48788
Show all »
Show » Show » 182 21.3 No 0