IDO1 - Gene info - The Human Protein Atlas

Gene name

IDO1 (HGNC Symbol)

Synonyms

IDO, INDO

Description

Indoleamine 2,3-dioxygenase 1 (HGNC Symbol)

Entrez gene summary

This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011]

Chromosome

Cytoband

p11.21

Chromosome location (bp)

39759794 - 39785963

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000131203 (version 75.37)

Entrez gene

3620

UniProt

P14902 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IDO1-001

ENSP00000430950
ENST00000518237

P14902
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P14902 [Direct mapping]
Indoleamine 2,3-dioxygenase 1
E5RGR8 [Target identity:44%; Query identity:100%]
Indoleamine 2,3-dioxygenase 1
E5RIX2 [Target identity:19%; Query identity:100%]
Indoleamine 2,3-dioxygenase 1
E5RH36 [Target identity:11%; Query identity:100%]
Indoleamine 2,3-dioxygenase 1

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   Oxidoreductases
   MEMSAT3 predicted membrane proteins
Enzymes
   ENZYME proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0002534 [cytokine production involved in inflammatory response]
GO:0002666 [positive regulation of T cell tolerance induction]
GO:0002678 [positive regulation of chronic inflammatory response]
GO:0002830 [positive regulation of type 2 immune response]
GO:0004833 [tryptophan 2,3-dioxygenase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006569 [tryptophan catabolic process]
GO:0006954 [inflammatory response]
GO:0007565 [female pregnancy]
GO:0007610 [behavior]
GO:0009055 [electron carrier activity]
GO:0019441 [tryptophan catabolic process to kynurenine]
GO:0020037 [heme binding]
GO:0030485 [smooth muscle contractile fiber]
GO:0032421 [stereocilium bundle]
GO:0032496 [response to lipopolysaccharide]
GO:0032693 [negative regulation of interleukin-10 production]
GO:0032735 [positive regulation of interleukin-12 production]
GO:0033555 [multicellular organismal response to stress]
GO:0033754 [indoleamine 2,3-dioxygenase activity]
GO:0034276 [kynurenic acid biosynthetic process]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0036269 [swimming behavior]
GO:0042130 [negative regulation of T cell proliferation]
GO:0043065 [positive regulation of apoptotic process]
GO:0044281 [small molecule metabolic process]
GO:0046007 [negative regulation of activated T cell proliferation]
GO:0046872 [metal ion binding]
GO:0070233 [negative regulation of T cell apoptotic process]

403

45.3

IDO1-002

ENSP00000253513
ENST00000253513

J3KN03
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J3KN03 [Target identity:100%; Query identity:100%]
Indoleamine 2,3-dioxygenase 1
E5RIX2 [Target identity:45%; Query identity:100%]
Indoleamine 2,3-dioxygenase 1
E5RH36 [Target identity:27%; Query identity:100%]
Indoleamine 2,3-dioxygenase 1

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Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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170

IDO1-003

ENSP00000429297
ENST00000518804

E5RIX2
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E5RIX2 [Target identity:100%; Query identity:100%]
Indoleamine 2,3-dioxygenase 1
E5RH36 [Target identity:60%; Query identity:100%]
Indoleamine 2,3-dioxygenase 1

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Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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9.2

IDO1-004

ENSP00000429933
ENST00000522840

E5RH36
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E5RH36 [Target identity:100%; Query identity:100%]
Indoleamine 2,3-dioxygenase 1

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Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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5.6

IDO1-005

ENSP00000430505
ENST00000522495

P14902
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GO:0002534 [cytokine production involved in inflammatory response]
GO:0002666 [positive regulation of T cell tolerance induction]
GO:0002678 [positive regulation of chronic inflammatory response]
GO:0002830 [positive regulation of type 2 immune response]
GO:0004833 [tryptophan 2,3-dioxygenase activity]
GO:0005829 [cytosol]
GO:0006569 [tryptophan catabolic process]
GO:0007565 [female pregnancy]
GO:0007610 [behavior]
GO:0009055 [electron carrier activity]
GO:0019441 [tryptophan catabolic process to kynurenine]
GO:0020037 [heme binding]
GO:0030485 [smooth muscle contractile fiber]
GO:0032421 [stereocilium bundle]
GO:0032496 [response to lipopolysaccharide]
GO:0032693 [negative regulation of interleukin-10 production]
GO:0032735 [positive regulation of interleukin-12 production]
GO:0033555 [multicellular organismal response to stress]
GO:0033754 [indoleamine 2,3-dioxygenase activity]
GO:0034276 [kynurenic acid biosynthetic process]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0044281 [small molecule metabolic process]
GO:0046007 [negative regulation of activated T cell proliferation]
GO:0046872 [metal ion binding]
GO:0070233 [negative regulation of T cell apoptotic process]

403

45.3

IDO1-008

ENSP00000428716
ENST00000519154

E5RGR8
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E5RGR8 [Target identity:100%; Query identity:100%]
Indoleamine 2,3-dioxygenase 1
E5RIX2 [Target identity:43%; Query identity:100%]
Indoleamine 2,3-dioxygenase 1
E5RH36 [Target identity:26%; Query identity:100%]
Indoleamine 2,3-dioxygenase 1

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Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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180

20.6

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.