Splice variant |
Ensembl |
UniProt |
Protein class |
Gene ontology |
Length (aa) |
Molecular mass (kDa) |
Signal peptide (predicted) |
Transmembrane regions (predicted)
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NR1H2-001 |
ENSP00000253727
ENST00000253727
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P55055 Show all »
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P55055 [Direct mapping]Oxysterols receptor LXR-beta F1D8P7 [Target identity:100%; Query identity:99%]Liver X nuclear receptor beta; Nuclear receptor subfamily 1, group H, member 2, isoform CRA_c M0QYE6 [Target identity:49%; Query identity:100%]Oxysterols receptor LXR-beta M0R1V8 [Target identity:45%; Query identity:100%]Oxysterols receptor LXR-beta M0QZF5 [Target identity:25%; Query identity:100%]Oxysterols receptor LXR-beta M0R3A7 [Target identity:8%; Query identity:100%]Oxysterols receptor LXR-beta
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Nuclear receptors Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001133 [sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0008270 [zinc ion binding] GO:0010467 [gene expression] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0010745 [negative regulation of macrophage derived foam cell differentiation] GO:0010867 [positive regulation of triglyceride biosynthetic process] GO:0010875 [positive regulation of cholesterol efflux] GO:0010884 [positive regulation of lipid storage] GO:0010887 [negative regulation of cholesterol storage] GO:0032270 [positive regulation of cellular protein metabolic process] GO:0032369 [negative regulation of lipid transport] GO:0032376 [positive regulation of cholesterol transport] GO:0042632 [cholesterol homeostasis] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0044255 [cellular lipid metabolic process] GO:0045723 [positive regulation of fatty acid biosynthetic process] GO:0045861 [negative regulation of proteolysis] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046965 [retinoid X receptor binding] GO:0048384 [retinoic acid receptor signaling pathway] GO:0048550 [negative regulation of pinocytosis] GO:0051006 [positive regulation of lipoprotein lipase activity] GO:0055088 [lipid homeostasis] GO:0060336 [negative regulation of interferon-gamma-mediated signaling pathway] GO:0090108 [positive regulation of high-density lipoprotein particle assembly] GO:0090187 [positive regulation of pancreatic juice secretion] GO:0090340 [positive regulation of secretion of lysosomal enzymes]
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460 |
51 |
No |
0 |
NR1H2-002 |
ENSP00000471194
ENST00000593926
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P55055 Show all »
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P55055 [Direct mapping]Oxysterols receptor LXR-beta F1D8P7 [Target identity:100%; Query identity:99%]Liver X nuclear receptor beta; Nuclear receptor subfamily 1, group H, member 2, isoform CRA_c M0QYE6 [Target identity:49%; Query identity:100%]Oxysterols receptor LXR-beta M0R1V8 [Target identity:45%; Query identity:100%]Oxysterols receptor LXR-beta M0QZF5 [Target identity:25%; Query identity:100%]Oxysterols receptor LXR-beta M0R3A7 [Target identity:8%; Query identity:100%]Oxysterols receptor LXR-beta
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Nuclear receptors Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014)
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Show »
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001133 [sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0008270 [zinc ion binding] GO:0010467 [gene expression] GO:0010745 [negative regulation of macrophage derived foam cell differentiation] GO:0010867 [positive regulation of triglyceride biosynthetic process] GO:0010875 [positive regulation of cholesterol efflux] GO:0010884 [positive regulation of lipid storage] GO:0010887 [negative regulation of cholesterol storage] GO:0032270 [positive regulation of cellular protein metabolic process] GO:0032369 [negative regulation of lipid transport] GO:0032376 [positive regulation of cholesterol transport] GO:0042632 [cholesterol homeostasis] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0044255 [cellular lipid metabolic process] GO:0045723 [positive regulation of fatty acid biosynthetic process] GO:0045861 [negative regulation of proteolysis] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046965 [retinoid X receptor binding] GO:0048384 [retinoic acid receptor signaling pathway] GO:0048550 [negative regulation of pinocytosis] GO:0051006 [positive regulation of lipoprotein lipase activity] GO:0060336 [negative regulation of interferon-gamma-mediated signaling pathway] GO:0090108 [positive regulation of high-density lipoprotein particle assembly] GO:0090187 [positive regulation of pancreatic juice secretion] GO:0090340 [positive regulation of secretion of lysosomal enzymes]
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460 |
51 |
No |
0 |
NR1H2-003 |
ENSP00000396151
ENST00000411902
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E7EWA6 Show all »
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E7EWA6 [Target identity:100%; Query identity:100%]Oxysterols receptor LXR-beta M0R3A7 [Target identity:11%; Query identity:100%]Oxysterols receptor LXR-beta
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Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001133 [sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0010875 [positive regulation of cholesterol efflux] GO:0010884 [positive regulation of lipid storage] GO:0042632 [cholesterol homeostasis] GO:0043401 [steroid hormone mediated signaling pathway] GO:0044255 [cellular lipid metabolic process] GO:0045861 [negative regulation of proteolysis] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046965 [retinoid X receptor binding] GO:0048384 [retinoic acid receptor signaling pathway] GO:0090108 [positive regulation of high-density lipoprotein particle assembly] GO:0090187 [positive regulation of pancreatic juice secretion] GO:0090340 [positive regulation of secretion of lysosomal enzymes]
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363 |
39.9 |
No |
0 |
NR1H2-005 |
ENSP00000472526
ENST00000599105
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M0R2F9 Show all »
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M0R2F9 [Target identity:100%; Query identity:100%]Oxysterols receptor LXR-beta M0QYE6 [Target identity:54%; Query identity:100%]Oxysterols receptor LXR-beta M0R1V8 [Target identity:50%; Query identity:100%]Oxysterols receptor LXR-beta B3KRG6 [Target identity:45%; Query identity:100%]Oxysterols receptor LXR-beta; cDNA FLJ34216 fis, clone FCBBF3022005, highly similar to OXYSTEROLS RECEPTOR LXR-BETA M0QZF5 [Target identity:27%; Query identity:100%]Oxysterols receptor LXR-beta M0R3A7 [Target identity:9%; Query identity:100%]Oxysterols receptor LXR-beta
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Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014)
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Show »
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001133 [sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0010875 [positive regulation of cholesterol efflux] GO:0010884 [positive regulation of lipid storage] GO:0042632 [cholesterol homeostasis] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0044255 [cellular lipid metabolic process] GO:0045861 [negative regulation of proteolysis] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046965 [retinoid X receptor binding] GO:0048384 [retinoic acid receptor signaling pathway] GO:0090108 [positive regulation of high-density lipoprotein particle assembly] GO:0090187 [positive regulation of pancreatic juice secretion] GO:0090340 [positive regulation of secretion of lysosomal enzymes]
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416 |
46 |
No |
0 |
NR1H2-006 |
ENSP00000470518
ENST00000597790
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M0QZF5 Show all »
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M0QZF5 [Target identity:100%; Query identity:100%]Oxysterols receptor LXR-beta M0R3A7 [Target identity:35%; Query identity:100%]Oxysterols receptor LXR-beta
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Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014)
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Show »
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001133 [sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0010875 [positive regulation of cholesterol efflux] GO:0010884 [positive regulation of lipid storage] GO:0042632 [cholesterol homeostasis] GO:0043565 [sequence-specific DNA binding] GO:0044255 [cellular lipid metabolic process] GO:0045861 [negative regulation of proteolysis] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046965 [retinoid X receptor binding] GO:0048384 [retinoic acid receptor signaling pathway] GO:0090108 [positive regulation of high-density lipoprotein particle assembly] GO:0090187 [positive regulation of pancreatic juice secretion] GO:0090340 [positive regulation of secretion of lysosomal enzymes]
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115 |
12.1 |
No |
0 |
NR1H2-008 |
ENSP00000472138
ENST00000597130
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M0R1V8 Show all »
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M0R1V8 [Target identity:100%; Query identity:100%]Oxysterols receptor LXR-beta M0QZF5 [Target identity:54%; Query identity:100%]Oxysterols receptor LXR-beta M0R3A7 [Target identity:19%; Query identity:100%]Oxysterols receptor LXR-beta
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Show »
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Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014)
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Show »
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001133 [sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0010875 [positive regulation of cholesterol efflux] GO:0010884 [positive regulation of lipid storage] GO:0042632 [cholesterol homeostasis] GO:0043565 [sequence-specific DNA binding] GO:0044255 [cellular lipid metabolic process] GO:0045861 [negative regulation of proteolysis] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046965 [retinoid X receptor binding] GO:0048384 [retinoic acid receptor signaling pathway] GO:0090108 [positive regulation of high-density lipoprotein particle assembly] GO:0090187 [positive regulation of pancreatic juice secretion] GO:0090340 [positive regulation of secretion of lysosomal enzymes]
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210 |
22.3 |
No |
0 |
NR1H2-009 |
ENSP00000469778
ENST00000597157
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M0QYE6 Show all »
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M0QYE6 [Target identity:100%; Query identity:100%]Oxysterols receptor LXR-beta M0R1V8 [Target identity:92%; Query identity:100%]Oxysterols receptor LXR-beta M0QZF5 [Target identity:50%; Query identity:100%]Oxysterols receptor LXR-beta M0R3A7 [Target identity:17%; Query identity:100%]Oxysterols receptor LXR-beta
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Show »
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Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014)
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Show »
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001133 [sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0010875 [positive regulation of cholesterol efflux] GO:0010884 [positive regulation of lipid storage] GO:0042632 [cholesterol homeostasis] GO:0043565 [sequence-specific DNA binding] GO:0044255 [cellular lipid metabolic process] GO:0045861 [negative regulation of proteolysis] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046965 [retinoid X receptor binding] GO:0048384 [retinoic acid receptor signaling pathway] GO:0090108 [positive regulation of high-density lipoprotein particle assembly] GO:0090187 [positive regulation of pancreatic juice secretion] GO:0090340 [positive regulation of secretion of lysosomal enzymes]
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228 |
24.1 |
No |
0 |
NR1H2-010 |
ENSP00000472271
ENST00000593532
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M0R229 Show all »
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M0R229 [Target identity:100%; Query identity:100%]Oxysterols receptor LXR-beta M0QZF5 [Target identity:65%; Query identity:100%]Oxysterols receptor LXR-beta M0R3A7 [Target identity:23%; Query identity:100%]Oxysterols receptor LXR-beta
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Show »
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Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014)
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Show »
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001133 [sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0010875 [positive regulation of cholesterol efflux] GO:0010884 [positive regulation of lipid storage] GO:0042632 [cholesterol homeostasis] GO:0043565 [sequence-specific DNA binding] GO:0044255 [cellular lipid metabolic process] GO:0045861 [negative regulation of proteolysis] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046965 [retinoid X receptor binding] GO:0048384 [retinoic acid receptor signaling pathway] GO:0090108 [positive regulation of high-density lipoprotein particle assembly] GO:0090187 [positive regulation of pancreatic juice secretion] GO:0090340 [positive regulation of secretion of lysosomal enzymes]
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176 |
18.7 |
No |
0 |
NR1H2-011 |
ENSP00000473099
ENST00000600355
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M0R3A7 Show all »
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M0R3A7 [Target identity:100%; Query identity:100%]Oxysterols receptor LXR-beta
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Show »
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Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014)
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Show »
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001133 [sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity] GO:0003677 [DNA binding] GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0005634 [nucleus] GO:0010875 [positive regulation of cholesterol efflux] GO:0010884 [positive regulation of lipid storage] GO:0042632 [cholesterol homeostasis] GO:0044255 [cellular lipid metabolic process] GO:0045861 [negative regulation of proteolysis] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046965 [retinoid X receptor binding] GO:0048384 [retinoic acid receptor signaling pathway] GO:0090108 [positive regulation of high-density lipoprotein particle assembly] GO:0090187 [positive regulation of pancreatic juice secretion] GO:0090340 [positive regulation of secretion of lysosomal enzymes]
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41 |
4 |
No |
0 |
NR1H2-014 |
ENSP00000471294
ENST00000598168
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M0R0K3 Show all »
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M0R0K3 [Target identity:100%; Query identity:100%]Oxysterols receptor LXR-beta M0QYE6 [Target identity:53%; Query identity:100%]Oxysterols receptor LXR-beta M0R1V8 [Target identity:48%; Query identity:100%]Oxysterols receptor LXR-beta M0QZF5 [Target identity:26%; Query identity:100%]Oxysterols receptor LXR-beta M0R3A7 [Target identity:9%; Query identity:100%]Oxysterols receptor LXR-beta
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Show »
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Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014)
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Show »
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001133 [sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0010875 [positive regulation of cholesterol efflux] GO:0010884 [positive regulation of lipid storage] GO:0042632 [cholesterol homeostasis] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0044255 [cellular lipid metabolic process] GO:0045861 [negative regulation of proteolysis] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046965 [retinoid X receptor binding] GO:0048384 [retinoic acid receptor signaling pathway] GO:0090108 [positive regulation of high-density lipoprotein particle assembly] GO:0090187 [positive regulation of pancreatic juice secretion] GO:0090340 [positive regulation of secretion of lysosomal enzymes]
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430 |
47.6 |
No |
0 |
NR1H2-201 |
ENSP00000445074
ENST00000542413
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B3KRG6 Show all »
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B3KRG6 [Target identity:100%; Query identity:100%]Oxysterols receptor LXR-beta; cDNA FLJ34216 fis, clone FCBBF3022005, highly similar to OXYSTEROLS RECEPTOR LXR-BETA
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Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014)
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Show »
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191 |
22.2 |
No |
0 |