NR0B2

GENE INFORMATION

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Gene name

NR0B2 (HGNC Symbol)

Synonyms

SHP

Description

Nuclear receptor subfamily 0, group B, member 2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

p36.11

Chromosome location (bp)

27237980 - 27240457

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000131910 (version 75.37)

Entrez gene

8431

UniProt

Q15466 (UniProt - Evidence at protein level)

neXtProt

NX_Q15466

Antibodypedia

NR0B2 antibodies
 

PROTEIN VIEW

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NR0B2-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NR0B2-001 ENSP00000254227
ENST00000254227
Q15466
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