COQ3

GENE INFORMATION

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Gene name

COQ3 (HGNC Symbol)

Synonyms

bA9819.1

Description

Coenzyme Q3 methyltransferase (HGNC Symbol)

Entrez gene summary

Ubiquinone, also known as coenzyme Q, or Q, is a critical component of the electron transport pathways of both eukaryotes and prokaryotes (Jonassen and Clarke, 2000 [PubMed 10777520]). This lipid consists of a hydrophobic isoprenoid tail and a quinone head group. The tail varies in length depending on the organism, but its purpose is to anchor coenzyme Q to the membrane. The quinone head group is responsible for the activity of coenzyme Q in the respiratory chain. The S. cerevisiae COQ3 gene encodes an O-methyltransferase required for 2 steps in the biosynthetic pathway of coenzyme Q. This enzyme methylates an early coenzyme Q intermediate, 3,4-dihydroxy-5-polyprenylbenzoic acid, as well as the final intermediate in the pathway, converting demethyl-ubiquinone to coenzyme Q. The COQ3 gene product is also capable of methylating the distinct prokaryotic early intermediate 2-hydroxy-6-polyprenyl phenol.[supplied by OMIM, Mar 2008]

Chromosome

6

Cytoband

q16.2

Chromosome location (bp)

99817276 - 99842080

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000132423 (version 75.37)

Entrez gene

51805

UniProt

Q9NZJ6 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NZJ6

Antibodypedia

COQ3 antibodies
 

PROTEIN VIEW

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COQ3-001
 
COQ3-002
 
COQ3-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

COQ3-001 ENSP00000254759
ENST00000254759
Q9NZJ6
Show all »
Show » Show » 369 41.1 No 0
COQ3-002 ENSP00000358243
ENST00000369240
Q5T063
Show all »
Show » Show » 141 15.4 No 0
COQ3-201 ENSP00000358245
ENST00000369242
Q5T063
Show all »
Show » Show » 141 15.4 No 0