GPS2

GENE INFORMATION

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Gene name

GPS2

Synonyms

Description

G protein pathway suppressor 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function. [provided by RefSeq, Jul 2008]

Chromosome

17

Cytoband

p13.1

Chromosome location (bp)

7214643 - 7218883

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000132522 (version 75.37)

Entrez gene

2874

UniProt

Q13227 (UniProt - Evidence at protein level)

neXtProt

NX_Q13227

Antibodypedia

GPS2 antibodies
 

PROTEIN VIEW

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GPS2-001
 
GPS2-004
 
GPS2-006
 
GPS2-012
 
GPS2-013
 
GPS2-014
 
GPS2-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GPS2-001 ENSP00000370104
ENST00000380728
Q13227
Show all »
Show » Show » 327 36.7 No 0
GPS2-004 ENSP00000379841
ENST00000389167
Q13227
Show all »
Show » Show » 327 36.7 No 0
GPS2-006 ENSP00000460836
ENST00000570780
B4DXA1
Show all »
Show » Show » 327 36.3 No 0
GPS2-012 ENSP00000459357
ENST00000574458
Show » 73 8 No 0
GPS2-013 ENSP00000458837
ENST00000573684
I3L1H4
Show all »
Show » 158 16.8 No 0
GPS2-014 ENSP00000461624
ENST00000577040
I3L4X7
Show all »
Show » Show » 259 29.3 No 0
GPS2-201 ENSP00000438697
ENST00000391950
B4DXA1
Show all »
Show » Show » 303 33.9 No 0