CDK4 - Gene info - The Human Protein Atlas

CDK4

TISSUE

SUBCELL

CELL LINE

CANCER

GENE INFORMATION

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Gene name	CDK4 (HGNC Symbol)
Synonyms	PSK-J3
Description	Cyclin-dependent kinase 4 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	q14.1
Chromosome location (bp)	58141510 - 58149796
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000135446 (version 75.37)
Entrez gene	1019
UniProt	P11802 (UniProt - Evidence at protein level)
neXtProt	NX_P11802
Antibodypedia	CDK4 antibodies

PROTEIN VIEW

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CDK4-001		CDK4-003		CDK4-004		CDK4-005		CDK4-006		CDK4-007		CDK4-008		CDK4-009		CDK4-010		CDK4-011		CDK4-012		CDK4-201		CDK4-202

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
CDK4-001	ENSP00000257904 ENST00000257904	P11802 Show all » « Hide P11802 [Direct mapping] Cyclin-dependent kinase 4 Q6LC83 [Target identity:75%; Query identity:100%] Cyclin dependent protein kinase; Cyclin-dependent kinase 4, isoform CRA_b F8VZ51 [Target identity:68%; Query identity:100%] Cyclin-dependent kinase 4 F8VWX7 [Target identity:66%; Query identity:100%] Cyclin-dependent kinase 4 F8VZZ0 [Target identity:61%; Query identity:100%] Cyclin-dependent kinase 4 B4DNF9 [Target identity:60%; Query identity:100%] Cyclin-dependent kinase 4; cDNA FLJ60730, highly similar to Cell division protein kinase 4 F8VYH9 [Target identity:56%; Query identity:100%] Cyclin-dependent kinase 4 F8VXD2 [Target identity:43%; Query identity:100%] Cyclin-dependent kinase 4 F8W1L8 [Target identity:37%; Query identity:100%] Cyclin-dependent kinase 4 F8VZ13 [Target identity:13%; Query identity:100%] Cyclin-dependent kinase 4	Show » « Hide Transferases CMGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins COSMIC Missense Mutations COSMIC Germline Mutations Enzymes ENZYME proteins Kinases Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes COSMIC somatic mutations in cancer genes Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000278 [mitotic cell cycle] GO:0000307 [cyclin-dependent protein kinase holoenzyme complex] GO:0000785 [chromatin] GO:0004672 [protein kinase activity] GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005923 [tight junction] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0007623 [circadian rhythm] GO:0008284 [positive regulation of cell proliferation] GO:0009636 [response to toxic substance] GO:0010033 [response to organic substance] GO:0010288 [response to lead ion] GO:0010468 [regulation of gene expression] GO:0016301 [kinase activity] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0030332 [cyclin binding] GO:0031100 [organ regeneration] GO:0031965 [nuclear membrane] GO:0032403 [protein complex binding] GO:0033574 [response to testosterone stimulus] GO:0042127 [regulation of cell proliferation] GO:0042493 [response to drug] GO:0043065 [positive regulation of apoptotic process] GO:0045727 [positive regulation of translation] GO:0045793 [positive regulation of cell size] GO:0048146 [positive regulation of fibroblast proliferation] GO:0048471 [perinuclear region of cytoplasm] GO:0051301 [cell division] GO:0051726 [regulation of cell cycle] GO:0055093 [response to hyperoxia]	303	33.7	No	0
CDK4-003	ENSP00000448885 ENST00000553237	F8VYY1 Show all » « Hide F8VYY1 [Target identity:100%; Query identity:100%] Cyclin-dependent kinase 4	Show » « Hide COSMIC Germline Mutations COSMIC Missense Mutations Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups]	74	7.8	No	0
CDK4-004	ENSP00000447005 ENST00000549606	F8VZ13 Show all » « Hide F8VZ13 [Target identity:100%; Query identity:100%] Cyclin-dependent kinase 4	Show » « Hide COSMIC Germline Mutations COSMIC Missense Mutations Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000307 [cyclin-dependent protein kinase holoenzyme complex] GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] GO:0005634 [nucleus] GO:0005667 [transcription factor complex] GO:0005923 [tight junction] GO:0007165 [signal transduction] GO:0007623 [circadian rhythm] GO:0008284 [positive regulation of cell proliferation] GO:0009636 [response to toxic substance] GO:0010288 [response to lead ion] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0030332 [cyclin binding] GO:0031100 [organ regeneration] GO:0032403 [protein complex binding] GO:0033574 [response to testosterone stimulus] GO:0043065 [positive regulation of apoptotic process] GO:0045727 [positive regulation of translation] GO:0045793 [positive regulation of cell size] GO:0048471 [perinuclear region of cytoplasm] GO:0051726 [regulation of cell cycle] GO:0055093 [response to hyperoxia]	40	4.6	No	0
CDK4-005	ENSP00000449391 ENST00000551800	F8VXD2 Show all » « Hide F8VXD2 [Target identity:100%; Query identity:100%] Cyclin-dependent kinase 4	Show » « Hide COSMIC Germline Mutations COSMIC Missense Mutations Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000307 [cyclin-dependent protein kinase holoenzyme complex] GO:0004672 [protein kinase activity] GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005667 [transcription factor complex] GO:0005923 [tight junction] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0007623 [circadian rhythm] GO:0008284 [positive regulation of cell proliferation] GO:0009636 [response to toxic substance] GO:0010288 [response to lead ion] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0030332 [cyclin binding] GO:0031100 [organ regeneration] GO:0032403 [protein complex binding] GO:0033574 [response to testosterone stimulus] GO:0043065 [positive regulation of apoptotic process] GO:0045727 [positive regulation of translation] GO:0045793 [positive regulation of cell size] GO:0048471 [perinuclear region of cytoplasm] GO:0051726 [regulation of cell cycle] GO:0055093 [response to hyperoxia]	132	14.9	No	0
CDK4-006	ENSP00000448963 ENST00000552388	F8VYH9 Show all » « Hide F8VYH9 [Target identity:100%; Query identity:100%] Cyclin-dependent kinase 4 F8W1L8 [Target identity:67%; Query identity:100%] Cyclin-dependent kinase 4	Show » « Hide COSMIC Germline Mutations COSMIC Missense Mutations Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000307 [cyclin-dependent protein kinase holoenzyme complex] GO:0004672 [protein kinase activity] GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005667 [transcription factor complex] GO:0005923 [tight junction] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0007623 [circadian rhythm] GO:0008284 [positive regulation of cell proliferation] GO:0009636 [response to toxic substance] GO:0010288 [response to lead ion] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0030332 [cyclin binding] GO:0031100 [organ regeneration] GO:0032403 [protein complex binding] GO:0033574 [response to testosterone stimulus] GO:0043065 [positive regulation of apoptotic process] GO:0045727 [positive regulation of translation] GO:0045793 [positive regulation of cell size] GO:0048471 [perinuclear region of cytoplasm] GO:0051726 [regulation of cell cycle] GO:0055093 [response to hyperoxia]	170	18.7	No	0
CDK4-007	ENSP00000447779 ENST00000546489	F8VZ51 Show all » « Hide F8VZ51 [Target identity:100%; Query identity:100%] Cyclin-dependent kinase 4 F8VZZ0 [Target identity:89%; Query identity:100%] Cyclin-dependent kinase 4 F8VXD2 [Target identity:63%; Query identity:100%] Cyclin-dependent kinase 4	Show » « Hide MEMSAT-SVM predicted membrane proteins COSMIC Germline Mutations COSMIC Missense Mutations Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000307 [cyclin-dependent protein kinase holoenzyme complex] GO:0004672 [protein kinase activity] GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005667 [transcription factor complex] GO:0005923 [tight junction] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0007623 [circadian rhythm] GO:0008284 [positive regulation of cell proliferation] GO:0009636 [response to toxic substance] GO:0010288 [response to lead ion] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0030332 [cyclin binding] GO:0031100 [organ regeneration] GO:0032403 [protein complex binding] GO:0033574 [response to testosterone stimulus] GO:0043065 [positive regulation of apoptotic process] GO:0045727 [positive regulation of translation] GO:0045793 [positive regulation of cell size] GO:0048471 [perinuclear region of cytoplasm] GO:0051726 [regulation of cell cycle] GO:0055093 [response to hyperoxia]	208	23.5	No	0
CDK4-008	ENSP00000448098 ENST00000550419	F8VTV8 Show all » « Hide F8VTV8 [Target identity:100%; Query identity:100%] Cyclin-dependent kinase 4 F8VYH9 [Target identity:84%; Query identity:100%] Cyclin-dependent kinase 4 F8W1L8 [Target identity:57%; Query identity:100%] Cyclin-dependent kinase 4	Show » « Hide COSMIC Germline Mutations COSMIC Missense Mutations Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000307 [cyclin-dependent protein kinase holoenzyme complex] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005667 [transcription factor complex] GO:0005923 [tight junction] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0007623 [circadian rhythm] GO:0008284 [positive regulation of cell proliferation] GO:0009636 [response to toxic substance] GO:0010288 [response to lead ion] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0030332 [cyclin binding] GO:0031100 [organ regeneration] GO:0032403 [protein complex binding] GO:0033574 [response to testosterone stimulus] GO:0043065 [positive regulation of apoptotic process] GO:0045727 [positive regulation of translation] GO:0045793 [positive regulation of cell size] GO:0048471 [perinuclear region of cytoplasm] GO:0051726 [regulation of cell cycle] GO:0055093 [response to hyperoxia]	201	22	No	0
CDK4-009	ENSP00000447274 ENST00000547281	F8VZZ0 Show all » « Hide F8VZZ0 [Target identity:100%; Query identity:100%] Cyclin-dependent kinase 4 F8VXD2 [Target identity:70%; Query identity:100%] Cyclin-dependent kinase 4	Show » « Hide MEMSAT-SVM predicted membrane proteins COSMIC Germline Mutations COSMIC Missense Mutations Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000307 [cyclin-dependent protein kinase holoenzyme complex] GO:0004672 [protein kinase activity] GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005667 [transcription factor complex] GO:0005923 [tight junction] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0007623 [circadian rhythm] GO:0008284 [positive regulation of cell proliferation] GO:0009636 [response to toxic substance] GO:0010288 [response to lead ion] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0030332 [cyclin binding] GO:0031100 [organ regeneration] GO:0032403 [protein complex binding] GO:0033574 [response to testosterone stimulus] GO:0043065 [positive regulation of apoptotic process] GO:0045727 [positive regulation of translation] GO:0045793 [positive regulation of cell size] GO:0048471 [perinuclear region of cytoplasm] GO:0051726 [regulation of cell cycle] GO:0055093 [response to hyperoxia]	186	21	No	0
CDK4-010	ENSP00000449725 ENST00000547853		Show » « Hide COSMIC Germline Mutations COSMIC Missense Mutations Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		2	0.2	No	0
CDK4-011	ENSP00000449179 ENST00000552254	F8VWX7 Show all » « Hide F8VWX7 [Target identity:100%; Query identity:100%] Cyclin-dependent kinase 4 F8VYH9 [Target identity:83%; Query identity:100%] Cyclin-dependent kinase 4 F8W1L8 [Target identity:56%; Query identity:100%] Cyclin-dependent kinase 4	Show » « Hide COSMIC Germline Mutations COSMIC Missense Mutations Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000307 [cyclin-dependent protein kinase holoenzyme complex] GO:0004672 [protein kinase activity] GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005667 [transcription factor complex] GO:0005923 [tight junction] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0007623 [circadian rhythm] GO:0008284 [positive regulation of cell proliferation] GO:0009636 [response to toxic substance] GO:0010288 [response to lead ion] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0030332 [cyclin binding] GO:0031100 [organ regeneration] GO:0032403 [protein complex binding] GO:0033574 [response to testosterone stimulus] GO:0043065 [positive regulation of apoptotic process] GO:0045727 [positive regulation of translation] GO:0045793 [positive regulation of cell size] GO:0048471 [perinuclear region of cytoplasm] GO:0051726 [regulation of cell cycle] GO:0055093 [response to hyperoxia]	203	22.4	No	0
CDK4-012	ENSP00000446763 ENST00000552862	F8W1L8 Show all » « Hide F8W1L8 [Target identity:100%; Query identity:100%] Cyclin-dependent kinase 4	Show » « Hide COSMIC Germline Mutations COSMIC Missense Mutations Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000307 [cyclin-dependent protein kinase holoenzyme complex] GO:0004672 [protein kinase activity] GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005667 [transcription factor complex] GO:0005923 [tight junction] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0007623 [circadian rhythm] GO:0008284 [positive regulation of cell proliferation] GO:0009636 [response to toxic substance] GO:0010288 [response to lead ion] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0030332 [cyclin binding] GO:0031100 [organ regeneration] GO:0032403 [protein complex binding] GO:0033574 [response to testosterone stimulus] GO:0043065 [positive regulation of apoptotic process] GO:0045727 [positive regulation of translation] GO:0045793 [positive regulation of cell size] GO:0048471 [perinuclear region of cytoplasm] GO:0051726 [regulation of cell cycle] GO:0055093 [response to hyperoxia]	115	12.5	No	0
CDK4-201	ENSP00000316889 ENST00000312990	Q96BE9 Show all » « Hide Q96BE9 [Target identity:100%; Query identity:100%] CDK4 protein; Cyclin-dependent kinase 4; Cyclin-dependent kinase 4, isoform CRA_c	Show » « Hide COSMIC Germline Mutations COSMIC Missense Mutations Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups]	111	12	No	0
CDK4-202	ENSP00000439076 ENST00000540325	B4DNF9 Show all » « Hide B4DNF9 [Target identity:100%; Query identity:100%] Cyclin-dependent kinase 4; cDNA FLJ60730, highly similar to Cell division protein kinase 4 F8VZ13 [Target identity:21%; Query identity:100%] Cyclin-dependent kinase 4	Show » « Hide MEMSAT-SVM predicted membrane proteins COSMIC Germline Mutations COSMIC Missense Mutations Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000307 [cyclin-dependent protein kinase holoenzyme complex] GO:0004672 [protein kinase activity] GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005667 [transcription factor complex] GO:0005923 [tight junction] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0007623 [circadian rhythm] GO:0008284 [positive regulation of cell proliferation] GO:0009636 [response to toxic substance] GO:0010288 [response to lead ion] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0030332 [cyclin binding] GO:0031100 [organ regeneration] GO:0032403 [protein complex binding] GO:0033574 [response to testosterone stimulus] GO:0043065 [positive regulation of apoptotic process] GO:0045727 [positive regulation of translation] GO:0045793 [positive regulation of cell size] GO:0048471 [perinuclear region of cytoplasm] GO:0051301 [cell division] GO:0051726 [regulation of cell cycle] GO:0055093 [response to hyperoxia]	183	20.7	No	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.