GNS

GENE INFORMATION

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Gene name

GNS

Synonyms

Description

Glucosamine (N-acetyl)-6-sulfatase (HGNC Symbol)

Entrez gene summary

The product of this gene is a lysosomal enzyme found in all cells. It is involved in the catabolism of heparin, heparan sulphate, and keratan sulphate. Deficiency of this enzyme results in the accumulation of undegraded substrate and the lysosomal storage disorder mucopolysaccharidosis type IIID (Sanfilippo D syndrome). Mucopolysaccharidosis type IIID is the least common of the four subtypes of Sanfilippo syndrome. [provided by RefSeq, Jul 2008]

Chromosome

12

Cytoband

q14.3

Chromosome location (bp)

65107225 - 65153227

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000135677 (version 75.37)

Entrez gene

2799

UniProt

P15586 (UniProt - Evidence at protein level)

neXtProt

NX_P15586

Antibodypedia

GNS antibodies
 

PROTEIN VIEW

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GNS-001
 
GNS-002
 
GNS-006
 
GNS-007
 
GNS-008
 
GNS-010
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GNS-001 ENSP00000258145
ENST00000258145
P15586
Show all »
Show » Show » 552 62.1 Yes 0
GNS-002 ENSP00000438497
ENST00000543646
F6S8M0
Show all »
Show » Show » 584 65.7 Yes 0
GNS-006 ENSP00000444819
ENST00000542058
B4DYH8
Show all »
Show » Show » 532 60 Yes 0
GNS-007 ENSP00000413130
ENST00000418919
H7C3P4
Show all »
Show » Show » 496 56.4 No 0
GNS-008 ENSP00000445055
ENST00000545273
F5H4C6
Show all »
Show » Show » 248 28.5 No 0
GNS-010 ENSP00000437782
ENST00000540196
Show » Show » 303 34.6 No 0