GH2

GENE INFORMATION

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Gene name

GH2 (HGNC Symbol)

Synonyms

GH-V, GHL, GHV, hGH-V

Description

Growth hormone 2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. As in the case of its pituitary counterpart, growth hormone 1, the predominant isoform of this particular family member shows similar somatogenic activity, with reduced lactogenic activity. Mutations in this gene lead to placental growth hormone/lactogen deficiency. [provided by RefSeq, Jul 2008]

Chromosome

17

Cytoband

q23.3

Chromosome location (bp)

61957578 - 61959295

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000136487 (version 75.37)

Entrez gene

2689

UniProt

P01242 (UniProt - Evidence at protein level)

neXtProt

NX_P01242

Antibodypedia

GH2 antibodies
 

PROTEIN VIEW

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GH2-001
 
GH2-002
 
GH2-003
 
GH2-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GH2-001 ENSP00000409294
ENST00000423893
P01242
Show all »
Show » Show » 217 25 Yes 0
GH2-002 ENSP00000410618
ENST00000449787
P01242
Show all »
Show » Show » 202 23.1 Yes 0
GH2-003 ENSP00000333157
ENST00000332800
P01242
Show all »
Show » Show » 256 28.9 Yes 0
GH2-004 ENSP00000394122
ENST00000456543
P01242
Show all »
Show » Show » 245 27.1 Yes 0