USP20

GENE INFORMATION

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Gene name

USP20 (HGNC Symbol)

Synonyms

KIAA1003

Description

Ubiquitin specific peptidase 20 (HGNC Symbol)

Entrez gene summary

This gene encodes a ubiquitin specific processing protease that was first identified as a substrate of the VHL (von Hippel-Lindau disease) protein E3 ubiquitin ligase complex. In addition to being ubiquitinated by the VHL-E3 ligase complex, this enzyme deubiquitinates hypoxia-inducible factor (HIF)-1 alpha and thereby causes increased expression of HIF-1alpha targeted genes which play a role in angiogenesis, glucose metabolism, cell proliferation and metastasis. The enzyme encoded by this gene also regulates G-protein coupled receptor signaling by mediating the deubiquitination of beta-2 adrenergic receptor (ADRB2). This enzyme is a ubiquitously expressed thiolester hydrolase. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jan 2013]

Chromosome

9

Cytoband

q34.11

Chromosome location (bp)

132596977 - 132644107

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000136878 (version 75.37)

Entrez gene

10868

UniProt

Q9Y2K6 (UniProt - Evidence at protein level)

neXtProt

NX_Q9Y2K6

Antibodypedia

USP20 antibodies
 

PROTEIN VIEW

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USP20-001
 
USP20-002
 
USP20-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

USP20-001 ENSP00000361506
ENST00000372429
Q9Y2K6
Show all »
Show » Show » 914 102 No 0
USP20-002 ENSP00000351122
ENST00000358355
Q9Y2K6
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Show » Show » 914 102 No 0
USP20-003 ENSP00000313811
ENST00000315480
Q9Y2K6
Show all »
Show » Show » 914 102 No 0