SDCBP - Gene info - The Human Protein Atlas

Gene name

SDCBP (HGNC Symbol)

Synonyms

SYCL

Description

Syndecan binding protein (syntenin) (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Chromosome

Cytoband

q12.1

Chromosome location (bp)

59465483 - 59495419

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000137575 (version 75.37)

Entrez gene

6386

UniProt

O00560 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SDCBP-001

ENSP00000260130
ENST00000260130

O00560
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O00560 [Direct mapping]
Syntenin-1

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Phobius predicted membrane proteins
TMHMM predicted membrane proteins
Plasma proteins
Cytoskeleton related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0001948 [glycoprotein binding]
GO:0005109 [frizzled binding]
GO:0005137 [interleukin-5 receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005895 [interleukin-5 receptor complex]
GO:0005912 [adherens junction]
GO:0005925 [focal adhesion]
GO:0006612 [protein targeting to membrane]
GO:0006930 [substrate-dependent cell migration, cell extension]
GO:0007265 [Ras protein signal transduction]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0008022 [protein C-terminus binding]
GO:0008093 [cytoskeletal adaptor activity]
GO:0016020 [membrane]
GO:0019838 [growth factor binding]
GO:0030036 [actin cytoskeleton organization]
GO:0035556 [intracellular signal transduction]
GO:0042043 [neurexin family protein binding]
GO:0042327 [positive regulation of phosphorylation]
GO:0042470 [melanosome]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0045545 [syndecan binding]
GO:0046330 [positive regulation of JNK cascade]
GO:0046875 [ephrin receptor binding]
GO:0046982 [protein heterodimerization activity]
GO:0047485 [protein N-terminus binding]
GO:0050839 [cell adhesion molecule binding]
GO:0070062 [extracellular vesicular exosome]

298

32.4

SDCBP-002

ENSP00000411771
ENST00000413219

O00560
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O00560 [Direct mapping]
Syntenin-1

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298

32.4

SDCBP-003

ENSP00000409288
ENST00000447182

O00560
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O00560 [Direct mapping]
Syntenin-1

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297

32.3

SDCBP-004

ENSP00000395351
ENST00000424270

O00560
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O00560 [Direct mapping]
Syntenin-1

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292

31.8

SDCBP-005

ENSP00000428184
ENST00000523483

G5EA09
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G5EA09 [Target identity:100%; Query identity:100%]
Syndecan binding protein (Syntenin), isoform CRA_a; Syntenin-1

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Phobius predicted membrane proteins
TMHMM predicted membrane proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0005515 [protein binding]

318

34.8

SDCBP-006

ENSP00000430730
ENST00000520168

B4DHN5
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B4DHN5 [Target identity:100%; Query identity:100%]
Syntenin-1; cDNA FLJ55055, moderately similar to Syntenin-1

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Phobius predicted membrane proteins
TMHMM predicted membrane proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0005515 [protein binding]

239

SDCBP-012

ENSP00000397820
ENST00000447267

E9PBU7
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E9PBU7 [Target identity:100%; Query identity:100%]
Syntenin-1

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Phobius predicted membrane proteins
TMHMM predicted membrane proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0005515 [protein binding]

244

26.5

SDCBP-201

ENSP00000391687
ENST00000422546

O00560
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O00560 [Direct mapping]
Syntenin-1

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297

32.3

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.