MMP13

GENE INFORMATION

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Gene name

MMP13 (HGNC Symbol)

Synonyms

CLG3

Description

Matrix metallopeptidase 13 (collagenase 3) (HGNC Symbol)

Entrez gene summary

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]

Chromosome

11

Cytoband

q22.2

Chromosome location (bp)

102813724 - 102826463

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000137745 (version 75.37)

Entrez gene

4322

UniProt

P45452 (UniProt - Evidence at protein level)

neXtProt

NX_P45452

Antibodypedia

MMP13 antibodies
 

PROTEIN VIEW

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MMP13-001
 
MMP13-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MMP13-001 ENSP00000260302
ENST00000260302
P45452
Show all »
Show » Show » 471 53.8 Yes 0
MMP13-002 ENSP00000339672
ENST00000340273
G5E971
Show all »
Show » Show » 489 55.8 Yes 0