DNASE2B

GENE INFORMATION

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Gene name

DNASE2B (HGNC Symbol)

Synonyms

DLAD

Description

Deoxyribonuclease II beta (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene shares considerable sequence similarity to, and is structurally related to DNase II. The latter is a well characterized endonuclease that catalyzes DNA hydrolysis in the absence of divalent cations at acidic pH. Unlike DNase II which is ubiquitously expressed, expression of this gene product is restricted to the salivary gland and lungs. The gene has been localized to chromosome 1p22.3 adjacent (and in opposite orientation) to the uricase pseudogene. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

p31.1

Chromosome location (bp)

84864215 - 84880701

Protein evidence

Evidence at transcript level (all genes)

Ensembl

ENSG00000137976 (version 75.37)

Entrez gene

58511

UniProt

Q8WZ79 (UniProt - Evidence at transcript level)

neXtProt

NX_Q8WZ79

Antibodypedia

DNASE2B antibodies
 

PROTEIN VIEW

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DNASE2B-001
 
DNASE2B-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DNASE2B-001 ENSP00000359699
ENST00000370665
Q8WZ79
Show all »
Show » Show » 361 41.7 Yes 0
DNASE2B-002 ENSP00000359696
ENST00000370662
Q8WZ79
Show all »
Show » Show » 153 17.8 No 0