COX17

GENE INFORMATION

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Gene name

COX17

Synonyms

Description

COX17 cytochrome c oxidase copper chaperone (HGNC Symbol)

Entrez gene summary

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be involved in the recruitment of copper to mitochondria for incorporation into the COX apoenzyme. This protein shares 92% amino acid sequence identity with mouse and rat Cox17 proteins. This gene is no longer considered to be a candidate gene for COX deficiency. A pseudogene COX17P has been found on chromosome 13. [provided by RefSeq, Jul 2008]

Chromosome

3

Cytoband

q13.33

Chromosome location (bp)

119373360 - 119396301

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000138495 (version 75.37)

Entrez gene

10063

UniProt

Q14061 (UniProt - Evidence at protein level)

neXtProt

NX_Q14061

Antibodypedia

COX17 antibodies
 

PROTEIN VIEW

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COX17-001
 
COX17-002
 
COX17-004
 
COX17-005
 
COX17-006
 
COX17-007
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

COX17-001 ENSP00000261070
ENST00000261070
Q14061
Show all »
Show » Show » 63 6.9 No 0
COX17-002 ENSP00000417805
ENST00000468918
Q14061
Show all »
Show » Show » 63 6.9 No 0
COX17-004 ENSP00000417120
ENST00000486606
Show » Show » 58 6.3 No 0
COX17-005 ENSP00000417651
ENST00000484810
C9J8T6
Show all »
Show » Show » 98 10.9 No 0
COX17-006 ENSP00000417923
ENST00000497116
Q14061
Show all »
Show » Show » 63 6.9 No 0
COX17-007 ENSP00000420406
ENST00000490145
Show » 45 5 No 0