CILP

GENE INFORMATION

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Gene name

CILP (HGNC Symbol)

Synonyms

HsT18872

Description

Cartilage intermediate layer protein, nucleotide pyrophosphohydrolase (HGNC Symbol)

Entrez gene summary

Major alterations in the composition of the cartilage extracellular matrix occur in joint disease, such as osteoarthrosis. This gene encodes the cartilage intermediate layer protein (CILP), which increases in early osteoarthrosis cartilage. The encoded protein was thought to encode a protein precursor for two different proteins; an N-terminal CILP and a C-terminal homolog of NTPPHase, however, later studies identified no nucleotide pyrophosphatase phosphodiesterase (NPP) activity. The full-length and the N-terminal domain of this protein was shown to function as an IGF-1 antagonist. An allelic variant of this gene has been associated with lumbar disc disease. [provided by RefSeq, Sep 2010]

Chromosome

15

Cytoband

q22.31

Chromosome location (bp)

65488337 - 65503826

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000138615 (version 75.37)

Entrez gene

8483

UniProt

O75339 (UniProt - Evidence at protein level)

neXtProt

NX_O75339

Antibodypedia

CILP antibodies
 

PROTEIN VIEW

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CILP-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CILP-001 ENSP00000261883
ENST00000261883
O75339
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