CYP1A1 - Gene info - The Human Protein Atlas

Gene name

CYP1A1 (HGNC Symbol)

Synonyms

CP11, CYP1, P1-450, P450-C, P450DX

Description

Cytochrome P450, family 1, subfamily A, polypeptide 1 (HGNC Symbol)

Entrez gene summary

This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. [provided by RefSeq, Jul 2008]

Chromosome

Cytoband

q24.1

Chromosome location (bp)

75011883 - 75017951

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000140465 (version 75.37)

Entrez gene

1543

UniProt

P04798 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CYP1A1-001

ENSP00000369050
ENST00000379727

P04798
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P04798 [Direct mapping]
Cytochrome P450 1A1
A0N0X8 [Target identity:100%; Query identity:100%]
Cytochrome P450, family 1, subfamily A, polypeptide 1; Cytochrome P450, family 1, subfamily A, polypeptide 1, isoform CRA_a; cDNA, FLJ94514, Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 1(CYP1A1), mRNA
A4F4K4 [Target identity:49%; Query identity:100%]
Cytochrome P450 1A1
A4F3V8 [Target identity:34%; Query identity:100%]
Cytochrome P450 1A1

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   Oxidoreductases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Enzymes
   ENZYME proteins
   Phobius predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0001666 [response to hypoxia]
GO:0001889 [liver development]
GO:0003824 [catalytic activity]
GO:0004497 [monooxygenase activity]
GO:0005506 [iron ion binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006778 [porphyrin-containing compound metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0007568 [aging]
GO:0008283 [cell proliferation]
GO:0008395 [steroid hydroxylase activity]
GO:0009308 [amine metabolic process]
GO:0009404 [toxin metabolic process]
GO:0009611 [response to wounding]
GO:0009615 [response to virus]
GO:0009624 [response to nematode]
GO:0009635 [response to herbicide]
GO:0009636 [response to toxic substance]
GO:0009792 [embryo development ending in birth or egg hatching]
GO:0009804 [coumarin metabolic process]
GO:0009812 [flavonoid metabolic process]
GO:0010033 [response to organic substance]
GO:0010041 [response to iron(III) ion]
GO:0014070 [response to organic cyclic compound]
GO:0016491 [oxidoreductase activity]
GO:0016679 [oxidoreductase activity, acting on diphenols and related substances as donors]
GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen]
GO:0016711 [flavonoid 3'-monooxygenase activity]
GO:0016712 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen]
GO:0017143 [insecticide metabolic process]
GO:0017144 [drug metabolic process]
GO:0018894 [dibenzo-p-dioxin metabolic process]
GO:0019341 [dibenzo-p-dioxin catabolic process]
GO:0019369 [arachidonic acid metabolic process]
GO:0019373 [epoxygenase P450 pathway]
GO:0019825 [oxygen binding]
GO:0019899 [enzyme binding]
GO:0020037 [heme binding]
GO:0032094 [response to food]
GO:0032451 [demethylase activity]
GO:0032496 [response to lipopolysaccharide]
GO:0032502 [developmental process]
GO:0033189 [response to vitamin A]
GO:0042359 [vitamin D metabolic process]
GO:0042493 [response to drug]
GO:0042904 [9-cis-retinoic acid biosynthetic process]
GO:0043010 [camera-type eye development]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046483 [heterocycle metabolic process]
GO:0046677 [response to antibiotic]
GO:0046685 [response to arsenic-containing substance]
GO:0048565 [digestive tract development]
GO:0050665 [hydrogen peroxide biosynthetic process]
GO:0055093 [response to hyperoxia]
GO:0055114 [oxidation-reduction process]
GO:0060137 [maternal process involved in parturition]
GO:0070330 [aromatase activity]
GO:0070365 [hepatocyte differentiation]
GO:0070576 [vitamin D 24-hydroxylase activity]
GO:0070988 [demethylation]
GO:0097267 [omega-hydroxylase P450 pathway]
GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle]

512

58.2

CYP1A1-002

ENSP00000456585
ENST00000567032

P04798
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GO:0001666 [response to hypoxia]
GO:0005506 [iron ion binding]
GO:0005739 [mitochondrion]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006778 [porphyrin-containing compound metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0007568 [aging]
GO:0008283 [cell proliferation]
GO:0008395 [steroid hydroxylase activity]
GO:0009308 [amine metabolic process]
GO:0009611 [response to wounding]
GO:0009615 [response to virus]
GO:0009624 [response to nematode]
GO:0009635 [response to herbicide]
GO:0009792 [embryo development ending in birth or egg hatching]
GO:0009804 [coumarin metabolic process]
GO:0009812 [flavonoid metabolic process]
GO:0010041 [response to iron(III) ion]
GO:0014070 [response to organic cyclic compound]
GO:0016491 [oxidoreductase activity]
GO:0016679 [oxidoreductase activity, acting on diphenols and related substances as donors]
GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen]
GO:0016711 [flavonoid 3'-monooxygenase activity]
GO:0016712 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen]
GO:0017143 [insecticide metabolic process]
GO:0017144 [drug metabolic process]
GO:0019341 [dibenzo-p-dioxin catabolic process]
GO:0019369 [arachidonic acid metabolic process]
GO:0019373 [epoxygenase P450 pathway]
GO:0019825 [oxygen binding]
GO:0019899 [enzyme binding]
GO:0020037 [heme binding]
GO:0032094 [response to food]
GO:0032451 [demethylase activity]
GO:0032496 [response to lipopolysaccharide]
GO:0033189 [response to vitamin A]
GO:0042359 [vitamin D metabolic process]
GO:0042493 [response to drug]
GO:0042904 [9-cis-retinoic acid biosynthetic process]
GO:0043010 [camera-type eye development]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046677 [response to antibiotic]
GO:0046685 [response to arsenic-containing substance]
GO:0048565 [digestive tract development]
GO:0050665 [hydrogen peroxide biosynthetic process]
GO:0055093 [response to hyperoxia]
GO:0055114 [oxidation-reduction process]
GO:0060137 [maternal process involved in parturition]
GO:0070330 [aromatase activity]
GO:0070365 [hepatocyte differentiation]
GO:0070576 [vitamin D 24-hydroxylase activity]
GO:0097267 [omega-hydroxylase P450 pathway]

512

58.2

CYP1A1-003

ENSP00000378489
ENST00000395049

E7EMT5
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E7EMT5 [Target identity:100%; Query identity:100%]
Cytochrome P450 1A1

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   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   1TM proteins predicted by MDM
Predicted membrane proteins
   Prediction method-based
   # TM segments-based
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0005506 [iron ion binding]
GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen]
GO:0016712 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen]
GO:0020037 [heme binding]
GO:0055114 [oxidation-reduction process]

483

54.8

CYP1A1-004

ENSP00000457668
ENST00000564596

P04798
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P04798 [Direct mapping]
Cytochrome P450 1A1

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   Oxidoreductases
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   1TM proteins predicted by MDM
Enzymes
   ENZYME proteins
Predicted membrane proteins
   Prediction method-based
   # TM segments-based
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0001666 [response to hypoxia]
GO:0005506 [iron ion binding]
GO:0005739 [mitochondrion]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006778 [porphyrin-containing compound metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0007568 [aging]
GO:0008283 [cell proliferation]
GO:0008395 [steroid hydroxylase activity]
GO:0009308 [amine metabolic process]
GO:0009611 [response to wounding]
GO:0009615 [response to virus]
GO:0009624 [response to nematode]
GO:0009635 [response to herbicide]
GO:0009792 [embryo development ending in birth or egg hatching]
GO:0009804 [coumarin metabolic process]
GO:0009812 [flavonoid metabolic process]
GO:0010041 [response to iron(III) ion]
GO:0014070 [response to organic cyclic compound]
GO:0016491 [oxidoreductase activity]
GO:0016679 [oxidoreductase activity, acting on diphenols and related substances as donors]
GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen]
GO:0016711 [flavonoid 3'-monooxygenase activity]
GO:0017143 [insecticide metabolic process]
GO:0017144 [drug metabolic process]
GO:0019341 [dibenzo-p-dioxin catabolic process]
GO:0019369 [arachidonic acid metabolic process]
GO:0019373 [epoxygenase P450 pathway]
GO:0019825 [oxygen binding]
GO:0019899 [enzyme binding]
GO:0020037 [heme binding]
GO:0032094 [response to food]
GO:0032451 [demethylase activity]
GO:0032496 [response to lipopolysaccharide]
GO:0033189 [response to vitamin A]
GO:0042359 [vitamin D metabolic process]
GO:0042493 [response to drug]
GO:0042904 [9-cis-retinoic acid biosynthetic process]
GO:0043010 [camera-type eye development]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046677 [response to antibiotic]
GO:0046685 [response to arsenic-containing substance]
GO:0048565 [digestive tract development]
GO:0050665 [hydrogen peroxide biosynthetic process]
GO:0055093 [response to hyperoxia]
GO:0055114 [oxidation-reduction process]
GO:0060137 [maternal process involved in parturition]
GO:0070330 [aromatase activity]
GO:0070365 [hepatocyte differentiation]
GO:0070576 [vitamin D 24-hydroxylase activity]
GO:0097267 [omega-hydroxylase P450 pathway]

157

18.4

CYP1A1-005

ENSP00000455051
ENST00000569630

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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   Phobius predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0005506 [iron ion binding]
GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen]
GO:0020037 [heme binding]
GO:0055114 [oxidation-reduction process]

189

20.8

CYP1A1-006

ENSP00000455846
ENST00000566503

A4F3V8
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A4F3V8 [Target identity:100%; Query identity:100%]
Cytochrome P450 1A1

Show » « Hide

   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0001666 [response to hypoxia]
GO:0005506 [iron ion binding]
GO:0005739 [mitochondrion]
GO:0006778 [porphyrin-containing compound metabolic process]
GO:0007568 [aging]
GO:0008283 [cell proliferation]
GO:0008395 [steroid hydroxylase activity]
GO:0009308 [amine metabolic process]
GO:0009611 [response to wounding]
GO:0009615 [response to virus]
GO:0009624 [response to nematode]
GO:0009635 [response to herbicide]
GO:0009792 [embryo development ending in birth or egg hatching]
GO:0009804 [coumarin metabolic process]
GO:0009812 [flavonoid metabolic process]
GO:0010041 [response to iron(III) ion]
GO:0014070 [response to organic cyclic compound]
GO:0016679 [oxidoreductase activity, acting on diphenols and related substances as donors]
GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen]
GO:0016711 [flavonoid 3'-monooxygenase activity]
GO:0016712 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen]
GO:0017143 [insecticide metabolic process]
GO:0019341 [dibenzo-p-dioxin catabolic process]
GO:0019899 [enzyme binding]
GO:0020037 [heme binding]
GO:0032094 [response to food]
GO:0032451 [demethylase activity]
GO:0032496 [response to lipopolysaccharide]
GO:0033189 [response to vitamin A]
GO:0042493 [response to drug]
GO:0042904 [9-cis-retinoic acid biosynthetic process]
GO:0043010 [camera-type eye development]
GO:0046677 [response to antibiotic]
GO:0046685 [response to arsenic-containing substance]
GO:0048565 [digestive tract development]
GO:0050665 [hydrogen peroxide biosynthetic process]
GO:0055093 [response to hyperoxia]
GO:0055114 [oxidation-reduction process]
GO:0060137 [maternal process involved in parturition]
GO:0070365 [hepatocyte differentiation]

175

20.6

CYP1A1-007

ENSP00000455340
ENST00000562201

P04798
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P04798 [Direct mapping]
Cytochrome P450 1A1

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GO:0001666 [response to hypoxia]
GO:0005506 [iron ion binding]
GO:0005739 [mitochondrion]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006778 [porphyrin-containing compound metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0007568 [aging]
GO:0008283 [cell proliferation]
GO:0008395 [steroid hydroxylase activity]
GO:0009308 [amine metabolic process]
GO:0009611 [response to wounding]
GO:0009615 [response to virus]
GO:0009624 [response to nematode]
GO:0009635 [response to herbicide]
GO:0009792 [embryo development ending in birth or egg hatching]
GO:0009804 [coumarin metabolic process]
GO:0009812 [flavonoid metabolic process]
GO:0010041 [response to iron(III) ion]
GO:0014070 [response to organic cyclic compound]
GO:0016491 [oxidoreductase activity]
GO:0016679 [oxidoreductase activity, acting on diphenols and related substances as donors]
GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen]
GO:0016711 [flavonoid 3'-monooxygenase activity]
GO:0017143 [insecticide metabolic process]
GO:0017144 [drug metabolic process]
GO:0019341 [dibenzo-p-dioxin catabolic process]
GO:0019369 [arachidonic acid metabolic process]
GO:0019373 [epoxygenase P450 pathway]
GO:0019825 [oxygen binding]
GO:0019899 [enzyme binding]
GO:0020037 [heme binding]
GO:0032094 [response to food]
GO:0032451 [demethylase activity]
GO:0032496 [response to lipopolysaccharide]
GO:0033189 [response to vitamin A]
GO:0042359 [vitamin D metabolic process]
GO:0042493 [response to drug]
GO:0042904 [9-cis-retinoic acid biosynthetic process]
GO:0043010 [camera-type eye development]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046677 [response to antibiotic]
GO:0046685 [response to arsenic-containing substance]
GO:0048565 [digestive tract development]
GO:0050665 [hydrogen peroxide biosynthetic process]
GO:0055093 [response to hyperoxia]
GO:0055114 [oxidation-reduction process]
GO:0060137 [maternal process involved in parturition]
GO:0070330 [aromatase activity]
GO:0070365 [hepatocyte differentiation]
GO:0070576 [vitamin D 24-hydroxylase activity]
GO:0097267 [omega-hydroxylase P450 pathway]

189

20.8

CYP1A1-201

ENSP00000378488
ENST00000395048

P04798
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512

58.2

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.