PRDM16

GENE INFORMATION

? »

Gene name

PRDM16 (HGNC Symbol)

Synonyms

KIAA1675, MEL1, MGC166915, PFM13

Description

PR domain containing 16 (HGNC Symbol)

Entrez gene summary

The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

p36.32

Chromosome location (bp)

2985732 - 3355185

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000142611 (version 75.37)

Entrez gene

63976

UniProt

Q9HAZ2 (UniProt - Evidence at protein level)

neXtProt

NX_Q9HAZ2

Antibodypedia

PRDM16 antibodies
 

PROTEIN VIEW

? »
 
 
 
PRDM16-001
 
PRDM16-002
 
PRDM16-003
 
PRDM16-004
 
PRDM16-007
 
PRDM16-008
 
PRDM16-201
 
PRDM16-202
 
PRDM16-203
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PRDM16-001 ENSP00000270722
ENST00000270722
Q9HAZ2
Show all »
Show » Show » 1276 140.3 No 0
PRDM16-002 ENSP00000425796
ENST00000509860
H0YA13
Show all »
Show » Show » 1084 119.4 No 0
PRDM16-003 ENSP00000367643
ENST00000378391
Q9HAZ2
Show all »
Show » Show » 1257 138.2 No 0
PRDM16-004 ENSP00000476002
ENST00000463591
U3KQL6
Show all »
Show » 53 5.9 No 0
PRDM16-007 ENSP00000426975
ENST00000511072
D6RDW0
Show all »
Show » Show » 1178 129.8 No 0
PRDM16-008 ENSP00000421400
ENST00000514189
D6RFY3
Show all »
Show » Show » 1177 129.7 No 0
PRDM16-201 ENSP00000367651
ENST00000378398
Q9HAZ2
Show all »
Show » Show » 1276 140.3 No 0
PRDM16-202 ENSP00000407968
ENST00000441472
F8WEV3
Show all »
Show » Show » 1275 140.2 No 0
PRDM16-203 ENSP00000405253
ENST00000442529
D3YTA5
Show all »
Show » Show » 1256 138.1 No 0