PADI1

GENE INFORMATION

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Gene name

PADI1 (HGNC Symbol)

Synonyms

HPAD10, PAD1, PDI, PDI1

Description

Peptidyl arginine deiminase, type I (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type I enzyme is involved in the late stages of epidermal differentiation, where it deiminates filaggrin and keratin K1, which maintains hydration of the stratum corneum, and hence the cutaneous barrier function. This enzyme may also play a role in hair follicle formation. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

p36.13

Chromosome location (bp)

17531621 - 17572500

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000142623 (version 75.37)

Entrez gene

29943

UniProt

Q9ULC6 (UniProt - Evidence at protein level)

neXtProt

NX_Q9ULC6

Antibodypedia

PADI1 antibodies
 

PROTEIN VIEW

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PADI1-001
 
PADI1-201
 
PADI1-202
 
PADI1-203
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PADI1-001 ENSP00000364620
ENST00000375471
Q9ULC6
Show all »
Show » Show » 663 74.7 No 0
PADI1-201 ENSP00000396697
ENST00000413717
B4DPX6
Show all »
Show » Show » 178 20.4 No 0
PADI1-202 ENSP00000444833
ENST00000536552
B4DQP2
Show all »
Show » Show » 134 15.7 No 0
PADI1-203 ENSP00000444032
ENST00000537499
B4DDP3
Show all »
Show » Show » 220 25.4 No 0