TPM3

GENE INFORMATION

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Gene name

TPM3 (HGNC Symbol)

Synonyms

NEM1, TRK

Description

Tropomyosin 3 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the tropomyosin family of actin-binding proteins. Tropomyosins are dimers of coiled-coil proteins that provide stability to actin filaments and regulate access of other actin-binding proteins. Mutations in this gene result in autosomal dominant nemaline myopathy and other muscle disorders. This locus is involved in translocations with other loci, including anaplastic lymphoma receptor tyrosine kinase (ALK) and neurotrophic tyrosine kinase receptor type 1 (NTRK1), which result in the formation of fusion proteins that act as oncogenes. There are numerous pseudogenes for this gene on different chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

Chromosome

1

Cytoband

q21.3

Chromosome location (bp)

154127784 - 154167124

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000143549 (version 75.37)

Entrez gene

7170

UniProt

P06753 (UniProt - Evidence at protein level)

neXtProt

NX_P06753

Antibodypedia

TPM3 antibodies
 

PROTEIN VIEW

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 « 
 
TPM3-001
 
TPM3-003
 
TPM3-004
 
TPM3-005
 
TPM3-006
 
TPM3-009
 
TPM3-010
 
TPM3-011
 
TPM3-015
 
TPM3-016
 
TPM3-018
 
TPM3-020
 
TPM3-026
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TPM3-001 ENSP00000357516
ENST00000368530
P06753
Show all »
Show » Show » 285 32.9 No 0
TPM3-003 ENSP00000341653
ENST00000341485
Q5HYB6
Show all »
Show » Show » 232 27.2 No 0
TPM3-004 ENSP00000357521
ENST00000368533
P06753
Show all »
Show » Show » 248 29 No 0
TPM3-005 ENSP00000339378
ENST00000341372
Q5VU61
Show all »
Show » Show » 223 26.1 No 0
TPM3-006 ENSP00000357520
ENST00000328159
Q5VU58
Show all »
Show » Show » 248 28.9 No 0
TPM3-009 ENSP00000339035
ENST00000330188
P06753
Show all »
Show » Show » 248 28.9 No 0
TPM3-010 ENSP00000357518
ENST00000323144
P06753
Show all »
Show » Show » 247 28.8 No 0
TPM3-011 ENSP00000307712
ENST00000302206
Q5VU63
Show all »
Show » Show » 158 18.6 No 0
TPM3-015 ENSP00000271850
ENST00000271850
J3KN67
Show all »
Show » Show » 285 33.2 No 0
TPM3-016 ENSP00000426521
ENST00000509409
D6RFM2
Show all »
Show » 49 5.8 No 0
TPM3-018 ENSP00000426306
ENST00000515609
D6RGJ6
Show all »
Show » Show » 75 8.7 No 0
TPM3-020 ENSP00000422207
ENST00000509601
D6R904
Show all »
Show » Show » 95 11 No 0
TPM3-026 ENSP00000357517
ENST00000368531
P06753
Show all »
Show » Show » 247 29 No 0