LEFTY2

GENE INFORMATION

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Gene name

LEFTY2 (HGNC Symbol)

Synonyms

EBAF, LEFTA, LEFTYA, TGFB4

Description

Left-right determination factor 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and plays a role in left-right asymmetry determination of organ systems during development. The protein may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2010]

Chromosome

1

Cytoband

q42.12

Chromosome location (bp)

226124298 - 226129189

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000143768 (version 75.37)

Entrez gene

7044

UniProt

O00292 (UniProt - Evidence at protein level)

neXtProt

NX_O00292

Antibodypedia

LEFTY2 antibodies
 

PROTEIN VIEW

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LEFTY2-001
 
LEFTY2-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

LEFTY2-001 ENSP00000355785
ENST00000366820
O00292
Show all »
Show » Show » 366 40.9 Yes 0
LEFTY2-201 ENSP00000388009
ENST00000420304
O00292
Show all »
Show » Show » 332 37.1 Yes 0