PTPN7

GENE INFORMATION

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Gene name

PTPN7 (HGNC Symbol)

Synonyms

HEPTP, LC-PTP

Description

Protein tyrosine phosphatase, non-receptor type 7 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The non-catalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2010]

Chromosome

1

Cytoband

q32.1

Chromosome location (bp)

202116141 - 202130716

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000143851 (version 75.37)

Entrez gene

5778

UniProt

P35236 (UniProt - Evidence at protein level)

neXtProt

NX_P35236

Antibodypedia

PTPN7 antibodies
 

PROTEIN VIEW

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 « 
 
PTPN7-001
 
PTPN7-003
 
PTPN7-005
 
PTPN7-007
 
PTPN7-009
 
PTPN7-010
 
PTPN7-011
 
PTPN7-012
 
PTPN7-013
 
PTPN7-015
 
PTPN7-016
 
PTPN7-017
 
PTPN7-018
 
PTPN7-020
 
PTPN7-201
 
PTPN7-202
 
PTPN7-203
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PTPN7-001 ENSP00000309116
ENST00000309017
B4DDG6
Show all »
Show » Show » 465 52.3 No 0
PTPN7-003 ENSP00000356248
ENST00000367279
P35236
Show all »
Show » Show » 399 45 No 0
PTPN7-005 ENSP00000418416
ENST00000477554
J3KR55
Show all »
Show » Show » 441 49.1 No 0
PTPN7-007 ENSP00000419733
ENST00000480836
F8WEY3
Show all »
Show » 76 8.3 No 0
PTPN7-009 ENSP00000419523
ENST00000496197
F8WF08
Show all »
Show » 140 15.4 No 0
PTPN7-010 ENSP00000419196
ENST00000462815
F8WF66
Show all »
Show » Show » 116 12.9 No 0
PTPN7-011 ENSP00000420506
ENST00000495688
P35236
Show all »
Show » Show » 360 40.5 No 0
PTPN7-012 ENSP00000417410
ENST00000492451
C9JBA9
Show all »
Show » Show » 102 11.3 No 0
PTPN7-013 ENSP00000418129
ENST00000477625
Show » Show » 225 25.5 No 0
PTPN7-015 ENSP00000406042
ENST00000435759
C9JAW7
Show all »
Show » 153 16.3 No 0
PTPN7-016 ENSP00000417350
ENST00000486116
E9PE54
Show all »
Show » Show » 140 15.6 No 0
PTPN7-017 ENSP00000418837
ENST00000467283
C9IYI6
Show all »
Show » Show » 153 17 No 0
PTPN7-018 ENSP00000420434
ENST00000464870
E7EUM0
Show all »
Show » Show » 154 17.1 No 0
PTPN7-020 ENSP00000419993
ENST00000476061
H7C5I3
Show all »
Show » Show » 183 20.7 No 0
PTPN7-201 ENSP00000311133
ENST00000308986
P35236
Show all »
Show » Show » 360 40.5 No 0
PTPN7-202 ENSP00000444624
ENST00000543735
B4DDG6
Show all »
Show » Show » 189 21.5 No 0
PTPN7-203 ENSP00000438272
ENST00000544762
B4DX06
Show all »
Show » Show » 136 15.1 No 0